Department of Epidemiology, School of Public Health, University of Michigan, USA; Global Institute for Vaccine Equity, University of Michigan, USA.
Institute for Social Research, University of Michigan, USA.
Int J Infect Dis. 2021 May;106:105-114. doi: 10.1016/j.ijid.2021.03.067. Epub 2021 Mar 26.
Kenya has substantially improved child mortality between 1990 and 2019, with under-5 mortality decreasing from 104 to 43 deaths per 1000 live births. However, only two-thirds of Kenyan children receive all recommended vaccines by 1 year, making it essential to identify undervaccinated subpopulations. Internal migrants are a potentially vulnerable group at risk of decreased access to healthcare. This analysis explored how maternal migration within Kenya influences childhood vaccination.
Data were from the 2014 Kenya Demographic and Health Survey, a nationally representative cross-sectional survey. Logistic regressions assessed relationships between maternal migration and full and up-to-date child vaccination using inverse probability of treatment weighting. Two exposure variables were examined: migration status and stream (e.g. rural-urban). Multiple imputation was used to impute up-to-date status for children without vaccination cards to reduce selection bias.
After accounting for selection and confounding biases, all relationships between migration status and migration stream and full and up-to-date vaccination became statistically insignificant.
Null findings indicate that, in Kenya, characteristics enabling migration, rather than the process of migration itself, drive differential vaccination behavior between migrants and non-migrants. This finding is an important deviation from previous literature, which did not rigorously address important biases.
肯尼亚在 1990 年至 2019 年间大幅降低了儿童死亡率,5 岁以下儿童死亡率从每 1000 例活产死亡 104 例降至 43 例。然而,只有三分之二的肯尼亚儿童在 1 岁前接受了所有建议的疫苗接种,因此必须确定未充分接种疫苗的亚人群。国内移民是一个潜在脆弱的群体,面临着获得医疗保健机会减少的风险。本分析探讨了肯尼亚国内的产妇迁移如何影响儿童的疫苗接种情况。
数据来自 2014 年肯尼亚人口与健康调查,这是一项全国代表性的横断面调查。逻辑回归评估了产妇迁移与儿童完全和及时接种疫苗之间的关系,使用了治疗的逆概率加权。检验了两个暴露变量:迁移状况和迁移流(例如农村-城市)。采用多重插补法对无疫苗接种卡的儿童进行了及时接种状态的插补,以减少选择偏倚。
在考虑了选择和混杂偏倚后,迁移状况和迁移流与完全和及时接种疫苗之间的所有关系都变得没有统计学意义。
零发现表明,在肯尼亚,促进迁移的特征,而不是迁移本身的过程,导致了移民和非移民之间的疫苗接种行为存在差异。这一发现与以前的文献有重要的偏离,以前的文献没有严格解决重要的偏倚。