18F-FDG 和 68Ga-FAPI PET/CT 在磨玻璃密度结节评估中的应用。

18F-FDG and 68Ga-FAPI PET/CT in the Evaluation of Ground-Glass Opacity Nodule.

机构信息

From the Department of Nuclear Medicine & Minnan PET Center.

Department of Thoracic Surgery, Xiamen Cancer Center, The First Affiliated Hospital of Xiamen University, Xiamen, China.

出版信息

Clin Nucl Med. 2021 May 1;46(5):424-426. doi: 10.1097/RLU.0000000000003600.

DOI:10.1097/RLU.0000000000003600

PMID:33782300

Abstract

A 50-year-old woman with a newly detected pulmonary ground-glass opacity (GGO) nodule underwent PET/CT to determine the likelihood of malignancy. This patient was enrolled in the prospective study (NCT04588064) to determine the effectiveness of 18F-FDG and 68Ga-FAPI PET/CT for characterization of the GGO nodule. On PET/CT images, minimal 18F-FDG uptake but intense 68Ga-FAPI uptake was observed in this GGO nodule. This patient subsequently underwent video-assisted thoracoscopic surgery, and postoperative pathological examination confirmed the diagnosis of invasive adenocarcinoma. This case presented an example where 68Ga-FAPI PET/CT showed higher tracer uptake than 18F-FDG in the malignant GGO nodule.

摘要

一位 50 岁女性，新发现肺部磨玻璃密度结节（GGO），行 PET/CT 以确定恶性肿瘤的可能性。该患者入组前瞻性研究（NCT04588064），以评估 18F-FDG 和 68Ga-FAPI PET/CT 对 GGO 结节特征的有效性。在 PET/CT 图像上，该 GGO 结节观察到 18F-FDG 摄取最低，但 68Ga-FAPI 摄取最强。该患者随后接受了电视辅助胸腔镜手术，术后病理检查证实为浸润性腺癌。该病例提示 68Ga-FAPI PET/CT 在恶性 GGO 结节中的示踪剂摄取高于 18F-FDG。