London Research and Development Centre, Agriculture and Agri-Food Canada, 1391 Sandford Street, London, Ontario, N5V 4T3, Canada.
Curr Opin Virol. 2021 Jun;48:10-16. doi: 10.1016/j.coviro.2021.03.002. Epub 2021 Mar 27.
Plant viruses have evolved efficient mechanisms to move cell-to-cell through plasmodesmata (PD) for systemic infection. Potyviruses including many economically important viruses constitute the largest group of known plant-infecting RNA viruses. Potyviral intercellular movement is accomplished by the coordinated action of at least three viral proteins and diverse host components. It requires the viral coat protein and is interlinked with active virus replication that generates, through RNA-polymerase slippage, a small percentage of frameshift viral RNA for the production of another essential movement protein named P3N-PIPO. This PD-located protein targets the virus-encoded cylindrical inclusion protein to PD to form special conical structures for potyviral passage, possibly in the form of virion. Here, I highlight and discuss major advances of potyviral intercellular trafficking.
植物病毒已经进化出有效的机制，通过胞间连丝（PD）在细胞间移动，从而实现系统感染。包括许多具有经济重要性的病毒在内的马铃薯 Y 病毒属病毒构成了已知最大的一组侵染植物的 RNA 病毒。马铃薯 Y 病毒属的细胞间运动是由至少三种病毒蛋白和不同的宿主成分的协调作用完成的。它需要病毒外壳蛋白，并与活跃的病毒复制相互关联，通过 RNA 聚合酶滑动，产生一小部分移码病毒 RNA，用于产生另一种名为 P3N-PIPO 的必需运动蛋白。这种位于 PD 的蛋白将病毒编码的圆柱形内含蛋白靶向 PD，以形成用于马铃薯 Y 病毒属通过的特殊锥形结构，可能是以病毒体的形式。在这里，我强调并讨论了马铃薯 Y 病毒属细胞间运输的主要进展。
