Steininger H, Thierauf P
Pathologisches Institut der Universität Erlangen-Nürnberg.
Dtsch Med Wochenschr. 1988 Jun 16;113(24):978-82. doi: 10.1055/s-2008-1067753.
A 63-year-old man with arterial hypertension suffered from depression and suicidal wish after a cerebrovascular accident and transitory left hemiparesis. He was urgently admitted to hospital in severe metabolic acidosis which caused renal failure and coma, ending fatally within two days. At necropsy calcium oxalate crystals were found in the renal tubules and cerebral vessel walls with chemically induced meningoencephalitis. From these findings glycol poisoning was diagnosed. There was a lethal concentration of ethylene glycol in the urine. The toxic effects of ethylene glycol are due to its metabolites. The oxalate crystals are primarily of diagnostic importance.
一名63岁的男性患有动脉高血压，在脑血管意外和短暂性左半身轻瘫后出现抑郁和自杀倾向。他因严重代谢性酸中毒紧急入院，该酸中毒导致肾衰竭和昏迷，两天内死亡。尸检发现肾小管和脑血管壁中有草酸钙晶体，并伴有化学性脑膜炎。根据这些发现诊断为乙二醇中毒。尿液中乙二醇浓度达到致死水平。乙二醇的毒性作用归因于其代谢产物。草酸钙晶体主要具有诊断意义。
