Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Sheba Medical Center, Internal Medicine B, Tel-Aviv, Israel.
Lupus. 2021 Jun;30(7):1094-1099. doi: 10.1177/09612033211004726. Epub 2021 Apr 1.
Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease characterized by antibody production against a myriad of autoantigens. Familial Mediterranean fever (FMF) is a genetic autoinflammatory disorder, triggered by FMF-associated point genes mutations. It has been hypothesized that the two conditions rarely coexist.
The aim of this study was to examine the proportions of FMF among SLE patients compared with the general population without SLE. We hypothesized that the proportion of FMF among SLE patients might be higher than the general population.
To conduct this cross-sectional study, data of adult patients with a physician diagnosis of SLE were retrieved from Clalit Health Services database, the largest Health Maintenance Organization in Israel, serving 4,400,000 members. Chi-square and T-test was used for univariate analysis.
The study population included 4,886 SLE patients and 24,430 age and sex matched controls. Within the SLE group we detected a significantly higher proportion of FMF patients compared with non-SLE controls (0.68% and 0.21% respectively; p < 0.001).
Our study indicated that FMF is more prevalent in an Israeli population of SLE patients.
系统性红斑狼疮（SLE）是一种全身性自身免疫性炎症性疾病，其特征是产生针对多种自身抗原的抗体。家族性地中海热（FMF）是一种遗传性自身炎症性疾病，由 FMF 相关点基因突变引发。据推测，这两种疾病很少同时存在。
本研究旨在检查与无 SLE 的普通人群相比，SLE 患者中 FMF 的比例。我们假设 SLE 患者中 FMF 的比例可能高于普通人群。
为了进行这项横断面研究，从以色列最大的医疗保健组织 Clalit 健康服务数据库中检索了有医生诊断为 SLE 的成年患者的数据，该数据库服务于 440 万成员。使用卡方检验和 T 检验进行单变量分析。
研究人群包括 4886 名 SLE 患者和 24430 名年龄和性别匹配的对照者。在 SLE 组中，我们发现 FMF 患者的比例明显高于非 SLE 对照组（分别为 0.68%和 0.21%；p<0.001）。
我们的研究表明，FMF 在以色列 SLE 患者人群中更为普遍。
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