Interferon Regulatory Factor 5 () Gene Haplotypes Are Associated with Premature Coronary Artery Disease. Association of the Polymorphisms with Cardiometabolic Parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican Study.

Interferon regulatory factor 5 () has an important role in the inflammatory process, a fundamental component of coronary artery disease (CAD). Thus, the objective of this study was to evaluate the association of polymorphisms with the development of premature CAD (pCAD) and cardiometabolic parameters. polymorphisms (rs1874330, rs3778754, rs3757386, rs3757385, rs3807134, rs3807135, and rs6968563) were determined in 1116 pCAD patients and 1003 controls. Polymorphism distribution was similar in patients and controls; however, the haplotype analysis showed five haplotypes with a different distribution. (OR (odds ratio) = 1.248, = 0005) and (OR = 10.73, < 0.0001) were associated with a high risk, whereas (OR = 0.155, < 0.0001), (OR = 0.108, < 0.0001), and (OR = 0.014, < 0.0001) were associated with a low risk of pCAD. Associations with aspartate aminotransferase, hypertriglyceridemia, magnesium deficiency, triglycerides/HDL-C index, LDL-C, and adiponectin levels were observed in pCAD patients. In controls, associations with hypoalphalipoproteinemia, non-HDL-C, apolipoprotein B, hyperuricemia, TNF-α, IL-6, IL-15, valvular calcification, and subclinical hypothyroidism were observed. In summary, five haplotypes were associated with pCAD, two with high risk and three with low risk. Some polymorphisms were associated with cardiometabolic parameters in pCAD patients and control.