利用点击化学交联的透明质酸纳米凝胶的非侵入性局部给药系统。
Non-Invasive Topical Drug-Delivery System Using Hyaluronate Nanogels Crosslinked via Click Chemistry.
作者信息
Choi Hyunsik, Kwon Mina, Choi Hye Eun, Hahn Sei Kwang, Kim Ki Su
机构信息
Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), 77-Cheongam-ro, Nam-gu, Pohang, Gyeongbuk 790-784, Korea.
School of Chemical Engineering, College of Engineering, Pusan National University, 2 Busandaehak-ro 63 beon-gil, Geumjeong-gu, Busan 46241, Korea.
出版信息
Materials (Basel). 2021 Mar 18;14(6):1504. doi: 10.3390/ma14061504.
Hyaluronate (HA) has been widely investigated for noninvasive topical drug delivery of chemical drugs and biopharmaceuticals. However, previous noninvasive delivery systems have been facilitated mostly by chemical conjugation of drugs with HA, which can cause reduced therapeutic efficacy and safety issues in chemically modified drugs. Here, HA nanogels were synthesized by crosslinking via "click" chemistry for noninvasive topical delivery of a model drug without chemical modification. The model-drug-encapsulating HA nanogels could be uptaken to the skin melanoma cells in vitro by HA-mediated endocytosis. In addition, histological analysis showed that HA nanogels could be topically delivered to the deep skin and tongue tissues through the noninvasive delivery routes. Taken together, HA nanogels could be effectively used for the noninvasive topical delivery of various therapeutic drugs.
透明质酸盐（HA）已被广泛研究用于化学药物和生物制药的非侵入性局部给药。然而，以前的非侵入性给药系统大多是通过药物与HA的化学偶联来实现的，这可能会导致化学修饰药物的治疗效果降低和安全性问题。在此，通过“点击”化学交联合成了HA纳米凝胶，用于未经化学修饰的模型药物的非侵入性局部给药。包封模型药物的HA纳米凝胶可通过HA介导的内吞作用在体外被皮肤黑色素瘤细胞摄取。此外，组织学分析表明，HA纳米凝胶可通过非侵入性给药途径局部递送至深层皮肤和舌组织。综上所述，HA纳米凝胶可有效地用于各种治疗药物的非侵入性局部给药。
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