Thornton Fabian, Döllinger Michael, Kniesburges Stefan, Berry David, Alexiou Christoph, Schützenberger Anne
Department of Otorhinolaryngology, Division of Phoniatrics and Pediatric Audiology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Laryngeal Dynamics Laboratory, Division of Head and Neck Surgery, David Geffen School of Medicine at UCLA, 1000 Veteran Ave, 31-24 Rehab Center, Los Angeles, CA 90095-1794, USA.
Appl Sci (Basel). 2019 May;9(9). doi: 10.3390/app9091963. Epub 2019 May 13.
Normal voice is characterized by periodic oscillations of the vocal folds. On the other hand, disordered voice dynamics (e.g., subharmonic and aperiodic oscillations) are often associated with voice pathologies and dysphonia. Unfortunately, not all investigations may be conducted on human subjects; hence animal laryngeal studies have been performed for many years to better understand human phonation. The rabbit larynx has been shown to be a potential model of the human larynx. Despite this fact, only a few studies regarding the phonatory parameters of rabbit larynges have been performed. Further, to the best of our knowledge, no ex vivo study has systematically investigated phonatory parameters from high-speed, audio and subglottal pressure data with irregular oscillations. To remedy this, the present study analyzes experiments with sustained phonation in 11 ex vivo rabbit larynges for 51 conditions of disordered vocal fold dynamics. (1) The results of this study support previous findings on non-disordered data, that the stronger the glottal closure insufficiency is during phonation, the worse the phonatory characteristics are; (2) aperiodic oscillations showed worse phonatory results than subharmonic oscillations; (3) in the presence of both types of irregular vibrations, the voice quality (i.e., cepstral peak prominence) of the audio and subglottal signal greatly deteriorated compared to normal/periodic vibrations. In summary, our results suggest that the presence of both types of irregular vibration have a major impact on voice quality and should be considered along with glottal closure measures in medical diagnosis and treatment.
正常嗓音的特征是声带的周期性振荡。另一方面，嗓音动态紊乱（例如，次谐波和非周期性振荡）通常与嗓音疾病和发声障碍有关。不幸的是，并非所有研究都能在人类受试者身上进行；因此，多年来一直在进行动物喉部研究，以更好地了解人类发声。兔喉已被证明是人类喉部的一个潜在模型。尽管如此，关于兔喉发声参数的研究却很少。此外，据我们所知，尚无离体研究系统地从高速、音频和声门下压力数据中研究不规则振荡的发声参数。为了弥补这一点，本研究分析了11个离体兔喉在51种声带动态紊乱情况下持续发声的实验。（1） 本研究结果支持了先前关于无紊乱数据的发现，即发声时声门闭合不全越严重，发声特征越差；（2） 非周期性振荡的发声结果比次谐波振荡更差；（3） 在同时存在两种不规则振动的情况下，与正常/周期性振动相比，音频和声门下信号的嗓音质量（即谐波峰值突出度）大大恶化。总之，我们的结果表明，两种不规则振动的存在对嗓音质量有重大影响，在医学诊断和治疗中应与声门闭合措施一并考虑。
