Jacobs B B, Parks R C
Exp Hematol. 1978 Nov;6(10):785-90.
A graft-versus-host reaction (GVHR) was produced in adult F1 hybrid mice by the injection of 10(8) parental strain spleen cells and 8 days later they were challenged with allogeneic third-party tumor. BALB/c Leydig cell tumor (C4092), C57BL/6 sarcoma (30795), and DBA/1 melanoma (S91) often grew progressively in B6D1F1, CD1F1, B6CF1 or their reciprocal hybrid recipients, respectively, when GVHR had been induced in these animals. Control, without GVHR, hybrids always rejected the tumor. The C4092 tumor was serially transplantable in untreated hybrids after its initial passage in unrelated GVHR-treated mice; the S91 grew in its first passage into untreated B6CF1 mice but thereafter was rejected by these hybrids; while the B6 tumor 30795 grew progressively only in the initial GVHR-treated CD1F1 or reciprocal hybrids. Reduced immunogenicity of tumors resulting from passage in unrelated recipients immunosuppressed in association with a GVHR is comparable to allograft adaptation achieved by such techniques as organ culture pretreatment and presents an additional method for attenuating rejection of allotransplants.
通过注射10⁸个亲本品系脾细胞在成年F1杂交小鼠中引发移植物抗宿主反应（GVHR），8天后用同种异体第三方肿瘤对其进行攻击。当在这些动物中诱导出GVHR时，BALB/c Leydig细胞瘤（C4092）、C57BL/6肉瘤（30795）和DBA/1黑色素瘤（S91）通常分别在B6D1F1、CD1F1、B6CF1或它们的反向杂交受体中逐渐生长。没有GVHR的对照杂交种总是会排斥肿瘤。C4092肿瘤在无关的经GVHR处理的小鼠中首次传代后，可在未经处理的杂交种中连续传代；S91在首次传代到未经处理的B6CF1小鼠中生长，但此后被这些杂交种排斥；而B6肿瘤30795仅在最初经GVHR处理的CD1F1或反向杂交种中逐渐生长。与GVHR相关的在无关受体中免疫抑制的情况下传代导致的肿瘤免疫原性降低，与通过器官培养预处理等技术实现的同种异体移植适应相当，并提供了一种减轻同种异体移植排斥的额外方法。
