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基于临床分期和组织学分级的口腔癌分型手术

[Type-oriented surgery of oral cancer based on its clinical staging and histological grading].

作者信息

Yamamoto E, Kohama G

机构信息

Dept. of Oral Surgery, Sapporo Medical College.

出版信息

Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-2):1171-7.

PMID:3382194
Abstract

Type-oriented surgery for oral cancer according to its clinical staging and histological grading were applied for a total of 204 cases of oral squamous cell carcinoma. These cases were classified not only by staging (St.) into 111 at St. I, II and 93 at St. III, IV, but also by grading (Gr.) into 33 of Gr. 1, 80 of Gr. 2, 69 of Gr. 3 and 22 of Gr. 4 with a total points system consisting of differentiation, mitosis, nuclear atypism, mode of invasion and lymphocytic infiltration. The four operation methods used and their indication were local excision for St. I, II + Gr. 1 in 33 cases, partial resection for St. I, II + Gr. 2, 3 and St. III, IV + Gr. 1, 2 in 115 cases, composite operation for St. I - IV + Gr. 3, 4 in 52 cases and wide resection for St. IV + Gr. 2, 3 in only 4 cases, resulting in observed survival rates of 28/30 (93.3%), 85/106(80.1%), 30/48 (62.5%) and 3/3 (100%), respectively. The cumulative survival rate estimated by staging was 86.7% for St. I, II and 77.6% for St. III, IV. Among these, cases with a high grade of histological malignancy (Gr. 4) at any clinical stage had the most unfavorable survival rate, 34.7%. Therefore, it should be emphasized that composite operation with wide local excision is necessary for such patients in order to obtain a better prognosis.

摘要

根据临床分期和组织学分级,对204例口腔鳞状细胞癌患者实施了针对性手术。这些病例不仅按分期(St.)分为I、II期111例,III、IV期93例,还按分级(Gr.)分为1级33例、2级80例、3级69例和4级22例,采用包括分化、有丝分裂、核异型性、浸润方式和淋巴细胞浸润的总分系统进行分级。所采用的四种手术方法及其适应证分别为:I、II期+1级33例行局部切除;I、II期+2、3级以及III、IV期+1、2级115例行部分切除;I - IV期+3、4级52例行联合手术;仅IV期+2、3级4例行广泛切除,其观察到的生存率分别为28/30(93.3%)、85/106(80.1%)、30/48(62.5%)和3/3(100%)。按分期估计的累积生存率I、II期为86.7%,III、IV期为77.6%。其中,任何临床分期组织学恶性程度高(4级)的病例生存率最不理想,为34.7%。因此,应强调对于此类患者,为获得更好的预后,行广泛局部切除的联合手术是必要的。

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