Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA.
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
Clin Transplant. 2021 Jul;35(7):e14312. doi: 10.1111/ctr.14312. Epub 2021 Apr 19.
Data regarding marijuana (MJ) use among liver transplant (LT) candidates are limited. We set out to determine the incidence and pre- and post-LT outcomes of adult LT candidates with a self-reported history of MJ use.
Baseline clinical characteristics, waitlist, and post-LT outcomes of adult LT candidates from January 2010 to March 2017 were compared.
Among 2690 LT candidates, 630(23%) and 298(11%) reported a history of MJ use and use within the past 12 months, respectively. Although the proportion of MJ users increased over time(β = .76, p = .03), the proportion listed and transplanted did not change. Listing for LT increased with male (OR 1.24, 95% CI 11.01-1.52), MELD score (OR 1.08, 95% CI 1.01-1.15), HCC (OR 1.83, 95% CI 1.39-2.41) but decreased among MJ users (OR 0.67, 95% CI 0.50-0.91, p = .01). The median time to listing was longer among MJ users compared to non-users (115 vs. 87 days, p < .0005). Post-LT survival was similar in 83 MJ users and 306 non-users.
The proportion of MJ users among LT candidates is increasing. MJ users have a greater burden of psychosocial issues which may contribute to longer evaluations and lower rate of LT listing. Post-LT survival was not impacted by self-reported MJ use history.
关于大麻（MJ）在肝移植（LT）候选者中使用的数据有限。我们旨在确定有自我报告大麻使用史的成年 LT 候选者的发生率以及 LT 前后的结果。
比较了 2010 年 1 月至 2017 年 3 月期间成人 LT 候选者的基线临床特征、等待名单和 LT 后结果。
在 2690 名 LT 候选者中，分别有 630（23%）和 298（11%）报告有大麻使用史和过去 12 个月内使用史。尽管大麻使用者的比例随时间增加（β=0.76，p=0.03），但列出和移植的比例并未改变。LT 列出的可能性随男性（OR 1.24，95%CI 11.01-1.52）、MELD 评分（OR 1.08，95%CI 1.01-1.15）、HCC（OR 1.83，95%CI 1.39-2.41）而增加，但在大麻使用者中减少（OR 0.67，95%CI 0.50-0.91，p=0.01）。与非使用者相比，大麻使用者的列表时间中位数更长（115 天与 87 天，p<0.0005）。83 名大麻使用者和 306 名非使用者的 LT 后生存率相似。
LT 候选者中大麻使用者的比例正在增加。大麻使用者有更多的心理社会问题负担，这可能导致评估时间延长和 LT 列出率降低。自我报告的大麻使用史对 LT 后生存率没有影响。
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