Department of Vascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College; Beijing-China.
Anatol J Cardiol. 2021 Apr;25(4):236-242. doi: 10.14744/AnatolJCardiol.2020.99537.
We aimed to evaluate the incidence of organ cysts in patients with type A aortic dissection (TAAD) to assess the association between organ cysts and TAAD.
Between January 2018 and December 2018, all patients with TAAD undergoing aortic surgery at our center were enrolled into the study; patients undergoing isolated coronary artery bypass grafting at our center were selected as the control group. Baseline differences between the 2 groups were adjusted using propensity-score matching. The incidence of organ cysts was compared between the 2 groups in total and matched cohorts.
We enrolled 290 patients with TAAD and 293 patients with coronary artery disease (control group). The incidence of all organ cysts, liver cysts, renal cysts, and other organ cysts, was significantly higher in the TAAD group than in the control group (50.0% vs. 35.5%, p<0.001; 24.5% vs. 10.2%, p<0.001; 33.4% vs. 24.9%, p=0.023; and 6.2% vs. 1.5%, p=0.005; respectively). Among the 191 propensity score-matched patient pairs, the incidence of organ cysts, liver cysts, renal cysts, and other organ cysts was also significantly higher in the TAAD group than in the control group (57.6% vs. 30.9%, p<0.001; 28.8% vs. 11.0%, p<0.001; 39.3% vs. 19.9%, p<0.001; and 8.4% vs. 1.0%, p=0.001; respectively). The incidence of cysts with single-organ and multiple-organ involvement was also significantly higher in the TAAD group than in the control group (34.0% vs. 20.4%, p=0.003; and 23.6% vs. 10.5%, p=0.001).
Our results show a higher incidence of organ cysts in patients with TAAD which is indicative of a common pathogenetic pathway between organ cysts and aortic dissection.
评估 A 型主动脉夹层（TAAD）患者发生器官囊肿的情况，以评估器官囊肿与 TAAD 的相关性。
本研究纳入了 2018 年 1 月至 2018 年 12 月期间在我院接受主动脉手术的所有 TAAD 患者；选择同期在我院接受单纯冠状动脉旁路移植术的患者作为对照组。采用倾向评分匹配法调整两组间的基线差异。比较两组患者的总体和匹配队列中器官囊肿的发生率。
本研究共纳入 290 例 TAAD 患者和 293 例冠心病患者（对照组）。TAAD 组所有器官囊肿、肝囊肿、肾囊肿和其他器官囊肿的发生率均显著高于对照组（50.0%比 35.5%，p<0.001；24.5%比 10.2%，p<0.001；33.4%比 24.9%，p=0.023；6.2%比 1.5%，p=0.005）。在 191 对倾向评分匹配的患者中，TAAD 组的器官囊肿、肝囊肿、肾囊肿和其他器官囊肿的发生率仍显著高于对照组（57.6%比 30.9%，p<0.001；28.8%比 11.0%，p<0.001；39.3%比 19.9%，p<0.001；8.4%比 1.0%，p=0.001）。TAAD 组单一器官和多器官受累的囊肿发生率也显著高于对照组（34.0%比 20.4%，p=0.003；23.6%比 10.5%，p=0.001）。
我们的研究结果显示，TAAD 患者器官囊肿的发生率较高，提示器官囊肿与主动脉夹层之间存在共同的发病机制。
