In Bangladesh, more than one-fifth (20.5 percent) of the total population, that is 30.68 million is adolescents. Most of the adult smokers initiate smoking in their adolescent period. This study aimed to investigate parental influencing factors for the initiation of tobacco smoking in adolescence period among 15-19 years old college students of Dhaka city, Bangladesh. This was an unmatched case-control study. The information was collected from 91 ever-smokers in the case group and 91 never-smokers in the control group. The respondents were 11th and 12th-grade male college students selected from two colleges of Dhaka city, Bangladesh. The results were analysed using univariate, bivariate and multivariate analysis. Parental control variable was categorized by using Likert Scale. Around 68.7 percent (n=57) respondents were 18-19 years old who were ever-smoker and about 44 percent (n=40) ever-smokers initiated smoking at or below the age of 16. Father's smoking status was found significant (p value <0.05) in bivariate analysis. In binary logistic regression, respondents who received intermediate to low control from their father compared to high control (OR 3.35, 95% CI 1.08-10.38, p value 0.035), respondents who received intermediate to low control from their mother compared to high control (OR 3.73, 95% CI 1.07-13.05, p value 0.039), and presence of any smoking member in their family compared to who did not have (OR 6.23, 95% CI 2.57-15.12, p value 0.001) found significantly higher odds of being ever-smoker. Respondents whose mother passed up to 8 hours in a day with them compared to mothers who gave limited time (less than 1 hour) in a day was found significantly lower odds (OR 0.07, 95% CI 0.01-0.65, p value 0.019) which was a protective factor of being ever-smoker. The result of the study concludes that parental influencing factors had a significant role in tobacco smoking of college-going male adolescents. Parent focused tobacco prevention program may be effective to reduce tobacco smoking prevalence. Further interventional studies are required.