中国高血压患者基线血浆锌浓度与蛋白尿发展的前瞻性关联。
Prospective association between baseline plasma zinc concentration and development of proteinuria in Chinese hypertensive patients.
机构信息
Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangdong Provincial Clinical Research Center for Kidney Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, 510515, China.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
出版信息
J Trace Elem Med Biol. 2021 Jul;66:126755. doi: 10.1016/j.jtemb.2021.126755. Epub 2021 Apr 2.
OBJECTIVE
We aimed to evaluate the association between baseline plasma zinc and the development of proteinuria as well as possible effect modifiers in hypertensive patients.
METHODS
This is a subset of the China Stroke Primary Prevention Trial (CSPPT) Renal Sub-Study. In the CSPPT, participants were randomized to receive a daily oral dose of 1 tablet containing 10 mg enalapril and 0.8 mg folic acid or 1 tablet containing 10 mg enalapril only. A total of 783 participants with plasma zinc measurements and without proteinuria at baseline were included in the current study. The study outcome was the development of proteinuria during the follow-up, defined as a urine dipstick reading of trace or ≥1+ at the exit visit.
RESULTS
During a median follow-up duration of 4.4 years, the development of proteinuria occurred in 93 (11.9 %) participants. There was an inverse relation of baseline plasma zinc with the development of proteinuria (per SD increment; OR, 0.74, 95 % CI: 0.55-0.99), p for trend of quartiles = 0.005.
CONCLUSIONS
In Chinese hypertensive patients, there was a significant inverse association between baseline plasma zinc and the development of proteinuria, although plasma zinc remained in the reference range.
目的
评估基线血浆锌与蛋白尿发展之间的关系，并探讨高血压患者中可能的影响因素。
方法
这是中国脑卒中一级预防试验（CSPPT）肾脏子研究的一部分。在 CSPPT 中，参与者被随机分配接受每日口服 1 片含有 10 毫克依那普利和 0.8 毫克叶酸的药物或仅含 10 毫克依那普利的药物。共有 783 名参与者在基线时进行了血浆锌测量且无蛋白尿，纳入本研究。研究结果为随访期间蛋白尿的发展，定义为在退出时尿试纸读数为微量或≥1+。
结果
在中位随访 4.4 年期间，93 名（11.9%）参与者发生了蛋白尿。基线血浆锌与蛋白尿的发展呈负相关（每标准差增加；OR，0.74，95%CI：0.55-0.99），四分位数的趋势 p 值=0.005。
结论
在中国高血压患者中，基线血浆锌与蛋白尿的发展呈显著负相关，尽管血浆锌仍处于参考范围内。
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