Department of Plastic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Both the authors contributed equally to this article and shared the first authorship.
Cell Transplant. 2021 Jan-Dec;30:963689721989607. doi: 10.1177/0963689721989607.
Due to the high absorption rate of traditional autologous fat grafting, cell-assisted lipotransfer (CAL) and platelet-rich plasma (PRP)-assisted lipotransfer were developed. The purpose of this article was to evaluate the efficacy and safety of CAL and PRP in promoting the survival of autologous fat grafting through systematic review and meta-analysis. We searched Pubmed, Cochrane Library, Web of Science, and EMBASE for clinical studies on CAL and PRP-assisted lipotransfer published from January 2010 to January 2020. Then a meta-analysis was performed to assess the efficacy of CAL and PRP-assisted lipotransfer through data analysis of fat survival rate. We also assessed the incidence of complications and multiple operations to analyze their safety. A total of 36 studies (1697 patients) were included in this review. Regardless of the recipient area, CAL and PRP-assisted lipotransfer significantly improved the fat survival rate (CAL vs non-CAL: 71% vs 48%, < 0.0001; PRP vs non-PRP: 70% vs 40%, < 0.0001; CAL vs PRP: 71% vs 70%, = 0.7175). However, in large-volume fat grafting, such as breast reconstruction, both increased the incidence of complications and did not decrease the frequency of multiple operations after lipotransfer. Further prospective studies are needed to evaluate the clinical benefits of CAL and PRP-assisted lipotransfer.
由于传统自体脂肪移植的吸收率高，因此开发了细胞辅助脂肪转移术（CAL）和富含血小板的血浆（PRP）辅助脂肪转移术。本文的目的是通过系统评价和荟萃分析评估 CAL 和 PRP 辅助脂肪转移术促进自体脂肪移植存活率的效果和安全性。我们检索了 Pubmed、Cochrane 图书馆、Web of Science 和 EMBASE 中自 2010 年 1 月至 2020 年 1 月发表的关于 CAL 和 PRP 辅助脂肪转移术的临床研究。然后，通过对脂肪存活率数据的分析进行荟萃分析，以评估 CAL 和 PRP 辅助脂肪转移术的效果。我们还评估了并发症和多次手术的发生率，以分析其安全性。本综述共纳入 36 项研究（1697 例患者）。无论接受区域如何，CAL 和 PRP 辅助脂肪转移术均显著提高了脂肪存活率（CAL 与非 CAL：71%与 48%，<0.0001；PRP 与非 PRP：70%与 40%，<0.0001；CAL 与 PRP：71%与 70%，=0.7175）。然而，在大容量脂肪移植中，如乳房重建，两者均增加了并发症的发生率，且并未降低脂肪移植后的多次手术频率。需要进一步的前瞻性研究来评估 CAL 和 PRP 辅助脂肪转移术的临床获益。
