睾丸动脉包膜支和睾丸内分支阻力指数对少弱精子症不育男性的诊断准确性：一项病例对照研究。

Diagnostic accuracy of resistive index of capsular and intratesticular branches of testicular arteries in infertile men with oligoasthenospermia: A case-control study.

作者信息

Zolfaghar-Khani Mehdi, Majidi Hadi, Feizzadeh Behzad, Sabaghi Mojtaba

机构信息

Department of Radiology, Faculty of Medicine, Orthopedic Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Department of Urology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

出版信息

Biomedicine (Taipei). 2020 Dec 1;10(4):18-22. doi: 10.37796/2211-8039.1036. eCollection 2020.

DOI:10.37796/2211-8039.1036

PMID:33854930

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7735981/

Abstract

INTRODUCTION

Male infertility accounts for nearly 50% of couples' infertility. Only a few studies evaluate the diagnostic accuracy of resistive index (RI) of testicular arteries using color Doppler imaging to identify male infertility. The aim of this study was to investigate the diagnostic accuracy of RI of the capsular and intratesticular branches of testicular arteries in infertile men with oligoasthenospermia and its comparison with normal men.

MATERIAL AND METHODS

In a case-control study, 30 patients with oligoasthenospermia (case group) and 30 healthy controls who meet the inclusion criteria, were selected. For all patients, RI was measured using color Doppler ultrasonography in upper and lower testicular poles. Also, testicular volumes were measured for all participants.

RESULTS

Mean RI of the intratesticular artery (0.624 ± 0.051 versus 0.509 ± 0.054; P < 0.001) and capsular artery (0.663 ± 0.057 versus 0.557 ± 0.055; P < 0.001) were significantly higher in the case group compared to control group. The frequency of abnormal RI of intratesticular artery in the control (13.3%) and case (66.7%) groups were significantly different (OR: 13.0; 95% CI: 3.44-47.59; P < 0.001). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy (OA) of intratesticular artery RI were 66.67%, 86.67%, 83.33%, 72.22%, and 76.67%, respectively. The frequency of abnormal RI of capsular artery was 23.3% in the control group and 90.0% in the case group (OR: 29.57; 95% CI: 6.85-127.63; P < 0.001). The sensitivity, specificity, PPV, NPV and OA of capsular artery RI were 90.0%, 76.67%, 79.41%, 88.46% and 83.33%, respectively.

CONCLUSION

The results of this study indicated that assessing testicular Doppler RI of capsular and intratesticular branches of the testicular arteries, as a bio-imaging biomarker, may be a valuable non-invasive and simple complementary diagnostic modality with a high diagnostic value in identifying infertile men with oligoasthenospermia.

摘要

引言

男性不育占夫妻不育问题的近50%。仅有少数研究评估了使用彩色多普勒成像技术测量睾丸动脉阻力指数（RI）以诊断男性不育的准确性。本研究旨在探讨睾丸动脉包膜支和睾丸内分支RI在少弱精子症不育男性中的诊断准确性，并与正常男性进行比较。

材料与方法

在一项病例对照研究中，选取了30例少弱精子症患者（病例组）和30例符合纳入标准的健康对照者。对所有患者，使用彩色多普勒超声在上、下睾丸极测量RI。此外，测量了所有参与者的睾丸体积。

结果

病例组睾丸内动脉的平均RI（0.624±0.051 vs 0.509±0.054；P<0.001）和包膜动脉的平均RI（0.663±0.057 vs 0.557±0.055；P<0.001）显著高于对照组。对照组（13.3%）和病例组（66.7%）睾丸内动脉RI异常的频率有显著差异（OR：13.0；95%CI：3.44 - 47.59；P<0.001）。睾丸内动脉RI的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）和总体准确性（OA）分别为66.67%、86.67%、83.33%、72.22%和76.67%。对照组包膜动脉RI异常的频率为23.3%，病例组为90.0%（OR：29.57；95%CI：6.85 - 127.63；P<0.001）。包膜动脉RI的敏感性、特异性、PPV、NPV和OA分别为90.0%、76.67%、79.41%、88.46%和83.33%。