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超声引导下椎旁神经周围糖皮质激素注射治疗 4 只犬椎间孔椎间盘突出相关难治性颈痛体征。

Ultrasound-guided paravertebral perineural glucocorticoid injection for signs of refractory cervical pain associated with foraminal intervertebral disk protrusion in four dogs.

出版信息

J Am Vet Med Assoc. 2021 May 1;258(9):999-1006. doi: 10.2460/javma.258.9.999.

Abstract

CASE DESCRIPTION

4 dogs, 7.5 to 10 years of age, were presented for evaluation of signs of chronic cervical pain and forelimb lameness secondary to cervical foraminal intervertebral disk protrusion (IVDP). All dogs were refractory to ≥ 2 weeks of conservative management including strict rest and pain management with anti-inflammatory drugs, methocarbamol, and gabapentin.

CLINICAL FINDINGS

The MRI findings included left foraminal IVDP at C2-3 causing mild C3 nerve root compression (dog 1), multifocal degenerative disk disease with mild focal left-sided disk protrusion at C6-7 without associated spinal cord or nerve root compression (dog 2), left foraminal C6-7 IVDP with suspected focal spinal cord atrophy or mild compression (dog 3), and right foraminal C6-7 IVDP and multifocal cervical intervertebral disk degeneration with annulus fibrosus protrusion (dog 4).

TREATMENT AND OUTCOME

Ultrasound-guided paravertebral perineural injections with methylprednisolone acetate (1 mg/kg [0.45 mg/lb]) at the C3 nerve root in dog 1 and at the C7 nerve root in the other 3 dogs were performed. Injections were repeated at intervals of 4 weeks to 3 months on the basis of clinical response. None of the dogs had any complications from the procedures. For dogs 1 and 4, there was complete resolution of lameness and signs of cervical pain following perineural injections, and for dog 3, there was complete resolution of lameness and only minimal residual cervical pain. Dog 2 did not have long-lasting improvement.

CLINICAL RELEVANCE

Findings indicated that ultrasound-guided paravertebral perineural injection can be an effective treatment of cervical foraminal IVDP for some dogs. Additional studies to determine appropriate case selection and better assess the overall success rate and risks associated with this technique are warranted.

摘要

病例描述

4 只犬,年龄 7.5 至 10 岁,因颈椎椎间孔椎间盘突出(IVDP)继发慢性颈痛和前肢跛行而就诊。所有犬均对至少 2 周的保守治疗无反应,包括严格休息和使用抗炎药、美索巴莫和加巴喷丁进行疼痛管理。

临床发现

MRI 检查结果包括 C2-3 左侧椎间孔 IVDP 导致轻度 C3 神经根受压(犬 1)、C6-7 多灶性退行性椎间盘疾病伴轻度左侧椎间盘突出但无脊髓或神经根受压(犬 2)、C6-7 左侧椎间孔 C6-7 IVDP 伴疑似局灶性脊髓萎缩或轻度压迫(犬 3)和 C6-7 右侧椎间孔 IVDP 及多灶性颈椎椎间盘退行性变伴纤维环突出(犬 4)。

治疗和结果

在犬 1 的 C3 神经根和其余 3 只犬的 C7 神经根行超声引导下椎旁神经周围注射甲泼尼龙醋酸酯(1mg/kg[0.45mg/lb])。根据临床反应,每 4 至 3 周重复注射。所有犬均未出现与手术相关的并发症。对于犬 1 和犬 4,神经周围注射后跛行和颈痛完全缓解;对于犬 3,跛行完全缓解,仅残留轻微的颈痛;犬 2 没有持久的改善。

临床相关性

研究结果表明,超声引导下椎旁神经周围注射可能是治疗某些犬颈椎椎间孔 IVDP 的有效方法。需要进一步研究来确定合适的病例选择,并更好地评估该技术的总体成功率和相关风险。

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