Department of Translational Medicine, Diagnostic Radiology, Lund University, Lund, Sweden
Department of Imaging and Functional Medicine, Skåne University Hospital, Malmö, Sweden.
Thorax. 2021 Oct;76(10):1040-1043. doi: 10.1136/thoraxjnl-2020-214523. Epub 2021 Apr 15.
Airspace dimension assessment with nanoparticles (AiDA) is a novel method to measure distal airspace radius non-invasively. In this study, AiDA radii were measured in 618 individuals from the population-based Swedish CArdiopulmonary BioImaging Study, SCAPIS. Subjects with emphysema detected by computed tomography were compared to non-emphysematous subjects. The 47 individuals with mainly mild-to-moderate visually detected emphysema had significantly larger AiDA radii, compared with non-emphysematous subjects (326±48 µm vs 291±36 µm); OR for emphysema per 10 µm: 1.22 (1.13-1.30, p<0.0001). Emphysema according to CT densitometry was similarly associated with larger radii compared with non-emphysematous CT examinations (316±41 µm vs 291 µm±26 µm); OR per 10 µm: 1.16 (1.08-1.24, p<0.0001). The results are in line with comparable studies. The results show that AiDA is a potential biomarker for emphysema in individuals in the general population.
用纳米颗粒进行气腔尺寸评估（AiDA）是一种无创测量远端气腔半径的新方法。在这项研究中，对基于人群的瑞典心肺生物成像研究（SCAPIS）中的 618 个人进行了 AiDA 半径测量。与非肺气肿个体相比，通过计算机断层扫描检测到肺气肿的个体进行了比较。47 名主要患有轻度至中度视觉检测到的肺气肿的个体与非肺气肿个体相比，AiDA 半径明显更大（326±48μm 比 291±36μm）；每 10μm 的肺气肿比值为 1.22（1.13-1.30，p<0.0001）。与非肺气肿 CT 检查相比，根据 CT 密度测定法的肺气肿同样与更大的半径相关（316±41μm 比 291μm±26μm）；每 10μm 的比值为 1.16（1.08-1.24，p<0.0001）。结果与类似的研究一致。结果表明，AiDA 是一般人群中肺气肿的潜在生物标志物。
