Michelet Mona, Selbaek Geir, Strand Bjørn Heine, Lund Anne, Engedal Knut, Bieber Anja, Gonçalves-Pereira Manuel, Hopper Louise, Irving Kate, Jelley Hannah, Marques Maria J, Orrell Martin, Portolani Daniel M, Sjölund Britt-Marie, Sköldunger Anders, Stephan Astrid, Verhey Frans, de Vugt Marjolein, Wolfs Claire, Woods Bob, Zanetti Orazio, Bergh Sverre
Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.
Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway.
Aging Ment Health. 2022 Apr;26(4):725-734. doi: 10.1080/13607863.2021.1910792. Epub 2021 Apr 16.
To examine prospectively the association between unmet needs for daytime activities and company and behavioural and psychological symptoms of dementia.
We included 451 people with mild or moderate dementia, from eight European countries, who were assessed three times over 12 months. Unmet needs were measured with the Camberwell Assessment of Need for the Elderly. Three sub-syndromes of the Neuropsychiatric Inventory-Questionnaire were regressed, one-by-one, against unmet needs for daytime activities and company, adjusting for demographic and clinical-functional covariates.
Unmet needs for daytime activities were associated with more affective symptoms at baseline, six and twelve months, mean 0.74 ( < 0.001), 0.76 ( < 0.001) and 0.78 ( = 0.001) points higher score respectively, and with more psychotic symptoms at baseline (mean 0.39 points, = 0.007) and at six months follow-up (mean 0.31 points, = 0.006). Unmet needs for company were associated with more affective symptoms at baseline, six and twelve months, mean 0.44 ( = 0.033), 0.67 ( < 0.001) and 0.91 ( < 0.001) points higher score respectively, and with more psychotic symptoms at baseline (mean 0.40 points, = 0.005) and at six months (mean 0.35 points, = 0.002) follow-up.
Interventions to reduce unmet needs for daytime activities and company could reduce affective and psychotic symptoms in people with dementia.
前瞻性研究日间活动需求未满足及陪伴情况与痴呆症行为和心理症状之间的关联。
我们纳入了来自八个欧洲国家的451名轻度或中度痴呆症患者，在12个月内对其进行了三次评估。使用坎伯韦尔老年人需求评估量表来衡量需求未满足情况。将神经精神科问卷的三个子综合征逐一与日间活动需求未满足及陪伴情况进行回归分析，并对人口统计学和临床功能协变量进行调整。
日间活动需求未满足与基线时、6个月和12个月时更多的情感症状相关，得分分别平均高出0.74（<0.001）、0.76（<0.001）和0.78（=0.001）分，且与基线时（平均0.39分，=0.007）和6个月随访时（平均0.31分，=0.006）更多的精神病性症状相关。陪伴需求未满足与基线时、6个月和12个月时更多的情感症状相关，得分分别平均高出0.44（=0.033）、0.67（<0.001）和0.91（<0.001）分，且与基线时（平均0.40分，=0.005）和6个月（平均0.35分，=0.002）随访时更多的精神病性症状相关。
减少日间活动需求未满足及陪伴需求未满足的干预措施可能会减少痴呆症患者的情感和精神病性症状。
