Garnier M, Perret G, Pilardeau P, Vaysse J, Rolland Y, Uzzan B, Vassy R
University of North Paris, School of Medicine, Laboratory of Experimental and Clinical Pharmacology, Bobigny, France.
Methods Find Exp Clin Pharmacol. 1988 Apr;10(4):259-62.
Rats were treated by ingesting forcibly 2 ml of a suspension of four different doses (100, 200, 300 and 400 mg/kg) of diosmin in carboxymethylcellulose (CMC) and were killed immediately or after 3 or 6 hours of fasting. Animals treated by CMC only in a similar way (gavage) exhibited a fall in red blood cell (RBC) membrane cholesterol and an increase in RBC rigidity at the third hour while osmotic fragility remained stable. Diosmin treatment opposed the rise in RBC rigidity evoked by the gavage and induced a dose-dependent decrease of the RBC membrane cholesterol over phospholipid ratio.
大鼠被强制灌胃2毫升羧甲基纤维素（CMC）中四种不同剂量（100、200、300和400毫克/千克）的地奥司明悬浮液，然后立即处死，或在禁食3或6小时后处死。仅以类似方式（灌胃）接受CMC处理的动物在第三小时时红细胞（RBC）膜胆固醇下降，红细胞刚性增加，而渗透脆性保持稳定。地奥司明处理对抗了灌胃引起的红细胞刚性增加，并导致红细胞膜胆固醇与磷脂比率呈剂量依赖性降低。
