早产儿和足月儿生后最初几个月呼出气一氧化氮浓度。
Exhaled nitric oxide in premature and mature infants during the first months of life.
机构信息
Department of Pediatrics and Adolescence Medicine, Nordsjællands Hospital, Capital Region of Denmark, Denmark; Department of Clinical Medicine, University of Copenhagen, Denmark.
Department of Pediatrics, Hvidovre Hospital, Capital Region of Denmark, Denmark.
出版信息
Nitric Oxide. 2021 Sep 1;113-114:7-12. doi: 10.1016/j.niox.2021.04.005. Epub 2021 Apr 15.
AIM
In this review, we aim to describe how exhaled Nitric Oxide(NO) changes during the first months of life in premature and mature infants.
METHOD
Review of the literature up to August 2020, on online, tidal breathing NO measurements in unsedated infants. The association between Fractional exhaled NO(FeNO) values, postnatal age, and prematurity was analysed using linear mixed modeling and Spearman's rank correlation.
RESULTS
Median FeNO during the first months of life was 5.9 and 8.5 ppb in premature and mature infants, respectively. The linear mixed model analysis showed a significant effect of postnatal age on FeNO (p = 0.007).
CONCLUSION
Our study suggests that FeNO is higher in mature infants than premature infants, and FeNO increased with postnatal age at approximately the same pace in both groups.
目的
本综述旨在描述早产儿和足月儿在生命最初几个月中呼出的一氧化氮（NO）如何变化。
方法
截至 2020 年 8 月，对在线非镇静婴儿潮气呼吸一氧化氮（NO）测量的文献进行综述。使用线性混合模型和斯皮尔曼等级相关分析来分析 FeNO 值、出生后年龄和早产之间的相关性。
结果
早产儿和足月儿在生命最初几个月的中位 FeNO 分别为 5.9 和 8.5 ppb。线性混合模型分析显示出生后年龄对 FeNO 有显著影响（p=0.007）。
结论
我们的研究表明，足月儿的 FeNO 高于早产儿，两组的 FeNO 都随出生后年龄的增加而以大致相同的速度增加。
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