Jing Chuya, Jing Changxin, Zheng Liangcheng, Hong Ganji, Zheng Jingjing, Yu Lu, Song Ningning, Zhang Tengkun, Ma Qilin, Fang Jie
Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Department of Endocrinology, The First Hospital of Yulin, Yulin, China.
Front Behav Neurosci. 2021 Apr 1;15:646337. doi: 10.3389/fnbeh.2021.646337. eCollection 2021.
Studies have shown that addictive behavior is associated with many brain regions, such as the insula, globus pallidus, amygdala, nucleus accumbens, and midbrain dopamine system, but only a few studies have explored the role of the dorsal striatum in addictive behavior. In June 2020, we started contacting 608 patients who were hospitalized between January 2017 and December 2019, and we recruited 11 smoking addicts with dorsal striatum damage and 20 controls with brain damage that did not involve the dorsal striatum (the damaged areas included the frontal lobe, temporal lobe, parietal lobe, brain stem, thalamus, internal capsule, and so on). All study participants had brain damage due to acute cerebral infarction. Disruption of smoking addiction was found to be significantly associated with the dorsal striatum (Phi = 0.794770, = 0.000015). Our findings suggested that patients in the dorsal striatum group were more likely to discontinue smoking than those in the non-dorsal striatum group. The characteristics of this interruption is that smoking can be quit more easily and quickly without recurrence and that the impulse to smoke is reduced. These results suggest that the dorsal striatum is a key area for addiction to smoking.
研究表明，成瘾行为与许多脑区有关，如脑岛、苍白球、杏仁核、伏隔核和中脑多巴胺系统，但只有少数研究探讨了背侧纹状体在成瘾行为中的作用。2020年6月，我们开始联系2017年1月至2019年12月期间住院的608名患者，招募了11名背侧纹状体受损的吸烟成瘾者和20名脑损伤但不涉及背侧纹状体的对照组（受损区域包括额叶、颞叶、顶叶、脑干、丘脑、内囊等）。所有研究参与者均因急性脑梗死导致脑损伤。发现吸烟成瘾的中断与背侧纹状体显著相关（Phi = 0.794770， = 0.000015）。我们的研究结果表明，背侧纹状体组的患者比非背侧纹状体组的患者更有可能戒烟。这种中断的特点是吸烟可以更容易、更快地戒掉且不再复发，吸烟冲动也会降低。这些结果表明，背侧纹状体是吸烟成瘾的关键区域。
