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双向 Glenn 吻合术高危缺氧患者肺血流量增加。

The increase of the pulmonary blood flow inhigh-risk hypoxic patients with a bidirectional Glenn anastomosis.

机构信息

Department of Pediatric Cardiac Surgery, Jagiellonian University Medical College, Kraków, Poland.

Department of Pediatric Cardiac Surgery, University Children's Hospital in Krakow, Kraków, Poland.

出版信息

Kardiol Pol. 2021;79(6):638-644. doi: 10.33963/KP.15939. Epub 2021 May 20.

Abstract

BACKGROUND

An additional shunt in single ventricle patients with Glenn anastomosis may increase pulmonary flow at the expense of ventricle volume overloading. The performance of the modification depends on pulmonary resistance, indicating better results in favorable hemodynamic conditions.

AIMS

The study aims at analyzing the influence of precisely adjusted pulsatile shunt in borderline high-risk Glenn patients on early and late results.

METHODS

The study involved 99 patients (including 21 children) with the bidirectional Glenn and accessory pulsatile shunt (BDGS group), and 78 patients with the classic bidirectional Glenn anastomosis (BDG group).

RESULTS

There was 1 death in the BDGS group and 4 deaths in the BDG group. No difference in mortality (P = 0.71) was found. The Fontan completion was achieved in 69 (88.5%) children in the BDG group and 18 (85.7%) patients in the BDGS group, without fatalities. No intergroup differences in postoperative pulmonary artery pressure (P = 0.10), ventilation time (P = 0.12), the McGoon ratio (P = 0.9), or chylothorax frequency (P = 0.14) were observed. Intensive care unit (P = 0.28) and hospitalization (P = 0.05) times were comparable. Echocardiography revealed no significant differences in the ventricle and atrioventricular valve function between groups. In the BDGS group, higher blood oxygen saturation (P = 0.03) and increase of the McGoon index (P = 0.002) were noted.

CONCLUSIONS

Bidirectional Glenn anastomosis with precisely adjusted accessory pulmonary blood flow provides stable hemodynamics and adequate oxygen saturation in borderline, profoundly hypoxic patients. An advantageous pulmonary artery development before Fontan completion was observed.

摘要

背景

在 Glenn 吻合术后的单心室患者中增加额外的分流可能会增加肺血流量,而使心室容量超负荷。该改良的性能取决于肺阻力,表明在有利的血流动力学条件下会有更好的结果。

目的

本研究旨在分析在边缘高危 Glenn 患者中精确调整的搏动性分流对早期和晚期结果的影响。

方法

本研究共纳入 99 例(包括 21 例儿童)行双向 Glenn 术+辅助搏动性分流(BDGS 组)和 78 例行经典双向 Glenn 吻合术(BDG 组)的患者。

结果

BDGS 组有 1 例死亡,BDG 组有 4 例死亡。两组死亡率无差异(P = 0.71)。BDG 组有 69 例(88.5%)儿童和 18 例(85.7%)BDGS 组患者完成 Fontan 手术,无死亡。两组术后肺动脉压(P = 0.10)、通气时间(P = 0.12)、McGoon 比值(P = 0.9)或乳糜胸发生率(P = 0.14)均无差异。两组 ICU 时间(P = 0.28)和住院时间(P = 0.05)相当。两组心室和房室瓣功能无显著差异。BDGS 组患者血氧饱和度较高(P = 0.03),McGoon 指数增加(P = 0.002)。

结论

在边缘、严重缺氧的患者中,精确调整辅助肺血流量的双向 Glenn 吻合术可提供稳定的血流动力学和充足的血氧饱和度。Fontan 完成前观察到有利的肺动脉发育。

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