Department of Biology, College of Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Hellenic Centre for Marine Research, Institute of Marine Biological Resources and Inland waters, 46.7 Athens-Sounio Ave., P.O. Box 712, 19013 Anavyssos Attika, Greece.
Mar Pollut Bull. 2021 Jun;167:112361. doi: 10.1016/j.marpolbul.2021.112361. Epub 2021 Apr 15.
On March 2020, hydroxychloroquine (HCQ) was recommended as a treatment for COVID-19 high risk patients. Following the massive and widespread use of HCQ worldwide, a discernible high quantity is anticipated to end-up through the sewage systems in marine coastal areas. A closed microcosm study was undertaken herein for 30 days where meiobenthic nematodes were exposed to a range of HCQ concentrations (3.162, 31.62 and 63.24 μg.ml). After one month of exposure in HCQ, the total abundances and Shannon-Wiener index of the assemblages decreased, whereas the individual mass and the Trophic Diversity Index increased at the highest concentrations. Overall, a numerical negative impact was observed for the epistrate feeders and non-selective deposit feeders, however, this benefited to the omnivores-carnivores, and particularly to the Oncholaimids. Such responses of the nematodes 2B and the corresponding taxa are bioindicative of current- or post-COVID-19 crisis risks in relation with the bioaccumulation of HCQ in seafood.
2020 年 3 月，羟氯喹 (HCQ) 被推荐用于治疗 COVID-19 高危患者。在全球范围内大量广泛使用 HCQ 之后，预计大量 HCQ 将最终通过海洋沿海地区的污水系统排放。本文进行了为期 30 天的密闭微宇宙研究，其中小型底栖线虫暴露于一系列 HCQ 浓度（3.162、31.62 和 63.24μg.ml）下。暴露于 HCQ 一个月后，群落的总丰度和香农-威纳指数下降，而个体质量和营养多样性指数在最高浓度下增加。总体而言，掠食者和非选择性沉积物摄食者的数量受到了负面影响，但这有利于杂食动物-肉食动物，特别是 Oncholaimids。线虫 2B 和相应分类群的这种反应是与 HCQ 在海鲜中生物累积有关的当前或 COVID-19 危机风险的生物标志物。
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