Azizi Samaneh, Mahdavi Reza, Mobasseri Majid, Aliasgharzadeh Soghra, Abbaszadeh Fatemeh, Ebrahimi-Mameghani Mehrangiz
Student Research Committee, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Nutrition Research Center, Department of Biochemistry and Diet Therapy, School of Nutrition & Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Phytother Res. 2021 Jun;35(6):3157-3166. doi: 10.1002/ptr.6997. Epub 2021 Apr 20.
This study investigated the impact of L-citrulline on glucose homeostasis, lipid profile, and inflammatory factors in overweight and obese patients with type 2 diabetes (T2D). In total, 54 participants with T2D were assigned to L-citrulline (3 g/day L-citrulline) or placebo groups and tested for 8 weeks. Serum levels of insulin, fasting glucose, hemoglobin A1c (HbA1c), lipid profile, tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hs-CRP), and L-citrulline were measured pre- and post-intervention. Totally, 45 patients were enrolled in the research. L-citrulline supplementation decreased serum levels of insulin (p = .025), glucose (p = .032), HbA1c (p = .001), HOMA-IR (p = .037), TNF-α (p = .036), and hs-CRP (p = .027) significantly. At the end of the study, despite the significant decrease in serum levels of triglyceride (p = .027) and the increase in high-density lipoprotein cholesterol levels (p < .001) in the L-citrulline group, no significant differences were found for these parameters between the groups. Moreover, no significant inter- and intra-group changes were observed for dietary intakes, anthropometric indices, total and low-density lipoprotein cholesterol levels (p > .05). In conclusion, L-citrulline supplementation might improve glucose homeostasis, some lipid factors and inflammatory markers in overweight and obese patients with T2D.
本研究调查了L-瓜氨酸对超重和肥胖的2型糖尿病（T2D）患者血糖稳态、血脂谱和炎症因子的影响。总共54名T2D参与者被分配到L-瓜氨酸组（每天3克L-瓜氨酸）或安慰剂组，并进行了8周的测试。在干预前后测量了胰岛素、空腹血糖、糖化血红蛋白（HbA1c）、血脂谱、肿瘤坏死因子-α（TNF-α）、高敏C反应蛋白（hs-CRP）和L-瓜氨酸的血清水平。共有45名患者参与了该研究。补充L-瓜氨酸显著降低了胰岛素（p = 0.025）、血糖（p = 0.032）、HbA1c（p = 0.001）、HOMA-IR（p = 0.037）、TNF-α（p = 0.036）和hs-CRP（p = 0.027）的血清水平。在研究结束时，尽管L-瓜氨酸组的甘油三酯血清水平显著降低（p = 0.027），高密度脂蛋白胆固醇水平升高（p < 0.001），但两组之间这些参数没有显著差异。此外，在饮食摄入量、人体测量指标、总胆固醇和低密度脂蛋白胆固醇水平方面，组间和组内均未观察到显著变化（p > 0.05）。总之，补充L-瓜氨酸可能会改善超重和肥胖的T2D患者的血糖稳态、一些血脂因子和炎症标志物。
