Reproductive Medical Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Curr Med Sci. 2021 Apr;41(2):236-249. doi: 10.1007/s11596-021-2342-1. Epub 2021 Apr 20.
Ovary plays an important role in the female reproductive system. The maintenance and regulation of ovarian function are affected by various physical and chemical factors. With the development of industrialization, environmental pollutants have caused great harm to public health. Phthalates, as a class of endocrine-disrupting chemicals (EDCs), are synthesized and used in large quantities as plasticizers due to their chemical properties. They are easily released into environment because of their noncovalent interactions with substances, causing human exposure and possibly impairing ovary. In recent years, more and more attention has been paid to the role of epigenetics in the occurrence and development of diseases. And it is urgent to study the role of methylation, gene imprinting, miRNA, and other epigenetic mechanisms in reproductive toxicology.
卵巢在女性生殖系统中起着重要作用。卵巢功能的维持和调节受到各种理化因素的影响。随着工业化的发展，环境污染物对公众健康造成了极大的危害。邻苯二甲酸酯作为一类内分泌干扰化学物质（EDCs），由于其化学性质，被大量合成并用作增塑剂。由于它们与物质的非共价相互作用，很容易释放到环境中，导致人类接触，并可能损害卵巢。近年来，人们越来越关注表观遗传学在疾病发生和发展中的作用。因此，迫切需要研究甲基化、基因印迹、miRNA 等表观遗传机制在生殖毒理学中的作用。
