Hillman Cancer Center, University of Pittsburgh Medical Center (UPMC), 5115 Centre Ave., Fl 4, Pittsburgh, PA, 15232, USA.
Chinese American Hematologist and Oncologist Network (CAHON), 555 East Wells Street, Suite 1100, Milwaukee, WI, 53202, USA.
J Hematol Oncol. 2021 Apr 21;14(1):66. doi: 10.1186/s13045-021-01077-3.
Antibodies and chimeric antigen receptor-engineered T cells (CAR-T) are increasingly used for cancer immunotherapy. Small molecule inhibitors targeting cellular oncoproteins and enzymes such as BCR-ABL, JAK2, Bruton tyrosine kinase, FLT3, BCL-2, IDH1, IDH2, are biomarker-driven chemotherapy-free agents approved for several major hematological malignancies. LOXO-305, asciminib, "off-the-shelf" universal CAR-T cells and BCMA-directed immunotherapeutics as well as data from clinical trials on many novel agents and regimens were updated at the 2020 American Society of Hematology (ASH) Annual Meeting. Major developments and updates for the therapy of hematological malignancies were delineated at the recent Winter Symposium and New York Oncology Forum from the Chinese American Hematologist and Oncologist Network (CAHON.org). This study summarized the latest updates on novel agents and regimens for hematological malignancies from the 2020 ASH annual meeting.
抗体和嵌合抗原受体工程 T 细胞(CAR-T)越来越多地用于癌症免疫治疗。针对细胞癌蛋白和酶的小分子抑制剂,如 BCR-ABL、JAK2、布鲁顿酪氨酸激酶、FLT3、BCL-2、IDH1、IDH2 等,是几种主要血液恶性肿瘤的基于生物标志物的无化疗批准药物。LOXO-305、asciminib、“现成的”通用 CAR-T 细胞和 BCMA 导向免疫疗法以及许多新型药物和方案的临床试验数据在 2020 年美国血液学会(ASH)年会上进行了更新。在最近的冬季研讨会和纽约肿瘤学论坛上,来自中美血液学家和肿瘤学家网络(CAHON.org)的专家阐述了血液恶性肿瘤治疗的主要进展和更新。本研究总结了 2020 年 ASH 年会血液恶性肿瘤新型药物和方案的最新进展。