German Center for Neurodegenerative Diseases (DZNE) Berlin, 10117 Berlin, Germany; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117 Berlin, Germany.
Cell Rep. 2021 Apr 20;35(3):109021. doi: 10.1016/j.celrep.2021.109021.
Sharp wave-ripples (SWRs) represent synchronous discharges of hippocampal neurons and are believed to play a major role in memory consolidation. A large body of evidence suggests that SWRs are exclusively generated in the CA3-CA2 network. In contrast, here, we provide several lines of evidence showing that the subiculum can function as a secondary SWRs generator. SWRs with subicular origin propagate forward into the entorhinal cortex as well as backward into the hippocampus proper. Our findings suggest that the output structures of the hippocampus are not only passively facilitating the transfer of SWRs to the cortex, but they also can actively contribute to the genesis of SWRs. We hypothesize that SWRs with a subicular origin may be important for the consolidation of information conveyed to the hippocampus via the temporoammonic pathway.
尖波涟漪（SWR）代表海马神经元的同步放电，被认为在记忆巩固中起主要作用。大量证据表明，SWR 仅在 CA3-CA2 网络中产生。相比之下，在这里，我们提供了几条证据表明，下托可以作为 SWR 的次要发生器。具有下托起源的 SWR 向前传播到内嗅皮层，也向后传播到海马体本身。我们的发现表明，海马体的输出结构不仅被动地促进 SWR 向皮层的转移，而且它们还可以主动促进 SWR 的产生。我们假设，具有下托起源的 SWR 可能对通过颞极通路传递到海马体的信息的巩固很重要。
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