3T 相位敏感反转恢复磁共振成像的快速三维灰质采集：在多发性硬化症患者中检测脊髓病变的应用。
3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery Magnetic Resonance Imaging at 3 Tesla: Application for detection of spinal cord lesions in patients with multiple sclerosis.
机构信息
Department of Neuroradiology, Foundation Adolphe de Rothschild Hospital, Paris, France.
Department of Clinical Research, Foundation Adolphe de Rothschild Hospital, Paris, France.
出版信息
PLoS One. 2021 Apr 22;16(4):e0247813. doi: 10.1371/journal.pone.0247813. eCollection 2021.
BACKGROUND AND PURPOSE
To compare 3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery (3D-FGAPSIR) with conventional 3D-Short-Tau Inversion Recovery (3D-STIR) and sagittal T1-and T2-weighted MRI dataset at 3 Tesla when detecting MS spinal cord lesions.
MATERIAL AND METHODS
This prospective single-center study was approved by an institutional review board and enrolled participants from December 2016 to August 2018. Two neuroradiologists blinded to all data, individually analyzed the 3D-FGAPSIR and the conventional datasets separately and in random order. Discrepancies were resolved by consensus by a third neuroradiologist. The primary judgment criterion was the number of MS spinal cord lesions. Secondary judgment criteria included lesion enhancement, lesion delineation, reader-reported confidence and lesion-to-cord-contrast-ratio. A Wilcoxon's test was used to compare the two datasets.
RESULTS
51 participants were included. 3D-FGAPSIR detected significantly more lesions than the conventional dataset (344 versus 171 respectively, p<0.001). Two participants had no detected lesion on the conventional dataset, whereas 3D-FGAPSIR detected at least one lesion. 3/51 participants had a single enhancing lesion detected by both datasets. Lesion delineation and reader-reported confidence were significantly higher with 3D-FGAPSIR: 4.5 (IQR 1) versus 2 (IQR 0.5), p<0.0001 and 4.5 (IQR 1) versus 2.5 (IQR 0.5), p<0.0001. Lesion-to-cord-contrast-ratio was significantly higher using 3D-FGAPSIR as opposed to 3D-STIR and T2: 1.4 (IQR 0,3) versus 0.4 (IQR 0,1) and 0.3 (IQR 0,1)(p = 0.04). Correlations with clinical data and inter- and intra-observer agreements were higher with 3D-FGAPSIR.
CONCLUSION
3D-FGAPSIR improved overall MS spinal cord lesion detection as compared to conventional set and detected all enhancing lesions.
背景与目的
在 3T 磁共振成像中，比较 3D-Fast Gray Matter Acquisition with Phase Sensitive Inversion Recovery（3D-FGAPSIR）与传统的 3D-Short-Tau Inversion Recovery（3D-STIR）和矢状位 T1 和 T2 加权 MRI 数据集在检测 MS 脊髓病变中的应用。
材料与方法
这项前瞻性单中心研究得到了机构审查委员会的批准，并于 2016 年 12 月至 2018 年 8 月期间招募了参与者。两位对所有数据均不知情的神经放射科医生分别独立地、随机地分析 3D-FGAPSIR 和传统数据集。由第三位神经放射科医生通过共识解决差异。主要判断标准是 MS 脊髓病变的数量。次要判断标准包括病变强化、病变描绘、读者报告的信心和病变与脊髓对比率。采用 Wilcoxon 检验比较两种数据集。
结果
共纳入 51 名参与者。3D-FGAPSIR 检测到的病变明显多于传统数据集（分别为 344 个和 171 个，p<0.001）。在传统数据集上，有 2 名参与者未检测到病变，而 3D-FGAPSIR 则至少检测到 1 个病变。在 3/51 名参与者中，两种数据集均检测到单个强化病变。3D-FGAPSIR 病变描绘和读者报告的信心显著更高：4.5（IQR 1）与 2（IQR 0.5），p<0.0001 和 4.5（IQR 1）与 2.5（IQR 0.5），p<0.0001。与 3D-STIR 和 T2 相比，3D-FGAPSIR 的病变与脊髓对比率显著更高：1.4（IQR 0，3）与 0.4（IQR 0，1）和 0.3（IQR 0，1）（p = 0.04）。与临床数据的相关性和观察者间及观察者内的一致性均较高。
结论
与传统数据集相比，3D-FGAPSIR 提高了 MS 脊髓病变的整体检测率，并可检测到所有强化病变。
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