具有印戒细胞形态并积聚泛素化细胞角蛋白5/6的基底细胞癌。
Basal cell carcinoma with signet ring cell morphology accumulating the ubiquitinated cytokeratin 5/6.
作者信息
Watanabe Ayako, Iida Naoshige, Enomoto Katsuhiko
机构信息
Department of Plastic and Reconstructive Surgery, Japanese Red Cross Akita Hospital, Akita, Japan
Department of Plastic and Reconstructive Surgery, Shonan Fujisawa Tokushukai Byoin, Fujisawa, Kanagawa, Japan.
出版信息
BMJ Case Rep. 2021 Apr 23;14(4):e241993. doi: 10.1136/bcr-2021-241993.
Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Inside of the cancer islands, many tumour cells showed an enlarged fine granular cytoplasm with the peripherally compressed nuclei, being similar to the SR cell. Immunohistochemical examination revealed dense accumulation of cytokeratin (CK) 5/6 and a faint signal of 34βE12 in SR cells. The reported myoepithelial markers were not detected. Interestingly, ubiquitin, a component of the ubiquitin-proteasome protein degradation system, was co-localised in the SR cells. These suggest, for the first time, that accumulation of the undegraded CK5/6 with ubiquitination results in the SR cell morphology. Our report showed that the aberrant keratin turnover is associated with the SR cell BCC.
具有印戒（SR）细胞形态的基底细胞癌（BCC）是BCC一种非常罕见的变体。在此，我们报告1例发生于79岁男性右侧脸颊皮肤的具有SR细胞形态的BCC。组织病理学检查显示，基底样细胞岛形状不规则，周边有特征性栅栏状排列。在癌岛内，许多肿瘤细胞表现为胞质细颗粒状增大，细胞核被挤压至周边，类似于SR细胞。免疫组织化学检查显示，SR细胞中细胞角蛋白（CK）5/6密集聚集，34βE12信号微弱。未检测到报道的肌上皮标志物。有趣的是，泛素（泛素-蛋白酶体蛋白降解系统的一个组成部分）在SR细胞中共定位。这些首次表明，未降解的CK5/6与泛素化的积累导致了SR细胞形态。我们的报告显示，异常的角蛋白周转与SR细胞型BCC有关。
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