Ningbo Key Lab of Polymer Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Ningbo Key Lab of Polymer Materials, Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.
Int J Biol Macromol. 2021 Jul 1;182:1037-1046. doi: 10.1016/j.ijbiomac.2021.04.105. Epub 2021 Apr 21.
Poly (lactic acid) (PLA) perforated membrane is typically obtained through the solvent-volatilization-induced or non-solvent-induced phase separation (NIPS) method. However, the residual organic solvents would unavoidably limit the application of PLA perforated membrane in biomedical and high-end water purification fields. Herein, an innovative solution-free method was proposed for preparing the PLA perforated membrane via a simple and environmentally friendly way. We have successfully fabricated the PLA perforated membrane using a physical foaming technique with CO as the blowing agent. By tuning the primary film thickness, saturation pressure, and foaming temperature, PLA perforated membrane's cell morphology could be accordingly adjusted. The PLA perforated membrane with a highly-ordered straight pore channel and high open cell content (OCC) approximately 72% was obtained under a mild condition. The formation mechanism of the PLA perforated membrane was discussed via the interaction of crystallization behavior and gas diffusion process. This green and solvent-free PLA perforated membrane possesses great potential for use in areas like the tissue engineering and high-end water purification.
聚乳酸（PLA）穿孔膜通常通过溶剂挥发诱导或非溶剂诱导相分离（NIPS）方法获得。然而，残留的有机溶剂不可避免地限制了 PLA 穿孔膜在生物医学和高端水净化领域的应用。本文提出了一种创新的无溶剂方法，通过简单环保的方法制备 PLA 穿孔膜。我们成功地使用 CO 作为发泡剂的物理发泡技术制备了 PLA 穿孔膜。通过调整初始膜厚、饱和压力和发泡温度，可以相应地调节 PLA 穿孔膜的细胞形态。在温和的条件下，获得了具有高度有序直通孔道和高开孔率（OCC）约 72%的 PLA 穿孔膜。通过结晶行为和气体扩散过程的相互作用讨论了 PLA 穿孔膜的形成机制。这种绿色无溶剂 PLA 穿孔膜在组织工程和高端水净化等领域具有很大的应用潜力。
