猫甲状腺肿瘤的病理和免疫组织化学特征。

Pathological and Immunohistochemical Characterization of Thyroid Neoplasms in Cats.

机构信息

Department of Veterinary Pathology, College of Veterinary Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.

出版信息

J Comp Pathol. 2021 Apr;184:44-55. doi: 10.1016/j.jcpa.2021.01.013. Epub 2021 Mar 2.

DOI:10.1016/j.jcpa.2021.01.013

PMID:33894877

Abstract

There are few pathological and immunohistochemical descriptions of thyroid neoplasms in cats. We investigated neoplasms of the thyroid in 31 cats (average age 15.6 years) in Southern Brazil. Most (96.8%) of these cases were classified as follicular adenomas and were predominantly unilateral and multinodular. Histologically, macrofollicular adenomas were the most common type observed. Carcinomas represented 3.2% of the investigated tumours. By immunohistochemical labelling, thyroglobulin was expressed more commonly than paired box gene 8 or thyroid transcription factor 1 in the follicular adenomas. One carcinoma was immunopositive for thyroglobulin, pancytokeratin, chromogranin A and synaptophysin, suggestive of a calcitonin-negative neuroendocrine carcinoma.

摘要

关于猫甲状腺肿瘤的病理学和免疫组织化学描述较少。我们研究了巴西南部 31 只猫（平均年龄 15.6 岁）的甲状腺肿瘤。这些病例中，大多数（96.8%）被归类为滤泡性腺瘤，主要为单侧和多结节性。组织学上，观察到的最常见的是巨滤泡性腺瘤。癌占所研究肿瘤的 3.2%。通过免疫组织化学标记，滤泡性腺瘤中甲状腺球蛋白的表达比配对盒基因 8 或甲状腺转录因子 1 更常见。有 1 种癌对甲状腺球蛋白、细胞角蛋白、嗜铬粒蛋白 A 和突触素呈免疫阳性，提示降钙素阴性神经内分泌癌。