Gorsline J, Latif S A, Morris D J
Department of Pathology and Laboratory Medicine, Miriam Hospital, Providence, RI 02906.
Am J Hypertens. 1988 Jul;1(3 Pt 1):272-5. doi: 10.1093/ajh/1.3.272.
The effects of dietary Na+ on 5 alpha- and 5 beta-reductase pathways of aldosterone metabolism in the liver were studied in male rats maintained on low, control, and high Na+ diets. A high Na+ diet caused significant increases in the synthesis of 5 beta-reduced metabolites, primarily 3 alpha, 5 beta-tetrahydroaldosterone; whereas a low Na+ diet stimulated the 5 alpha-reductase pathway causing increases in the synthesis of 5 alpha-dihydroaldosterone and 3 beta 5 alpha-tetrahydroaldosterone, as well as certain polar, hydroxylated metabolites of aldosterone. These studies demonstrate that dietary Na+, a known regulator of aldosterone synthesis, may also regulate enzymes involved in aldosterone metabolism in peripheral tissues.
在以低钠、正常钠和高钠饮食喂养的雄性大鼠中，研究了饮食中钠对肝脏中醛固酮代谢的5α-和5β-还原酶途径的影响。高钠饮食导致5β-还原代谢产物（主要是3α,5β-四氢醛固酮）的合成显著增加；而低钠饮食则刺激5α-还原酶途径，导致5α-二氢醛固酮和3β,5α-四氢醛固酮以及醛固酮的某些极性羟基化代谢产物的合成增加。这些研究表明，饮食中的钠作为醛固酮合成的已知调节因子，也可能调节外周组织中参与醛固酮代谢的酶。
