高强度间歇运动测试可刺激儿童生长激素分泌。

High-intensity interval exercise test stimulates growth hormone secretion in children.

机构信息

Pediatric Exercise Research and Genomic Center (PERC), University of California, Irvine, USA; Endocrine unit, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.

Endocrine unit, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel.

出版信息

Growth Horm IGF Res. 2021 Apr-Jun;57-58:101388. doi: 10.1016/j.ghir.2021.101388. Epub 2021 Apr 20.

DOI:10.1016/j.ghir.2021.101388

PMID:33906078

Abstract

BACKGROUND

exercise stimulates growth hormone (GH) secretion and may serve as a promising physiological test for the diagnosis of GH deficiency. However, exercise standardization for a feasible GH test is still lacking. The aim of the present study was to examine the GH secretion to high intensity interval exercise.

METHODS

Seventeen children (12.4 ± 2.6 years) with impaired growth rate performed high-intensity interval exercise test (HIIE) that included 10 intervals of 15 s all out pedaling against resistance determined by age, sex and weight on a cycle ergometer with 1-min active rest between each interval. Power output measurements were collected during the test. Blood samples were collected before, immediately after, 30, 45, and 60min after the beginning of the exercise test. GH response was compered to pharmacological provocation test (clonidine or glucagon).

RESULTS

HIIE led to a significant increase in GH levels (p < 0.001), with high correlation to GH response following pharmacological stimulation (r = 0.82, r = 0.80 for clonidine and glucagon respectively, p < 0.001) A significant correlation was found between mean peak power to body weight and the GH response (r = 0.50, p = 0.04). 83% of the participants who reached peak power > 10 watts/kg had normal GH secretion.

CONCLUSIONS

HIIE is a brief and individualized exercise protocol that may be used as a physiological provocation test for GH secretion. There might be a minimum of anaerobic power needed to induce adequate GH response during HIIE.

摘要

背景

运动刺激生长激素（GH）分泌，可作为诊断 GH 缺乏症的有前途的生理测试。然而，对于可行的 GH 测试，运动标准化仍然缺乏。本研究的目的是检查高强度间歇运动对 GH 分泌的影响。

方法

17 名生长速度受损的儿童（12.4 ± 2.6 岁）进行高强度间歇运动测试（HIIE），该测试包括在固定自行车上进行 10 次 15 秒的全力蹬踏，阻力根据年龄、性别和体重确定，每次间隔 1 分钟主动休息。在测试过程中收集功率输出测量值。在运动测试开始前、立即后、30 分钟、45 分钟和 60 分钟采集血液样本。将 GH 反应与药理学激发试验（可乐定或胰高血糖素）进行比较。

结果

HIIE 导致 GH 水平显著升高（p<0.001），与药理学刺激后的 GH 反应高度相关（r=0.82，r=0.80 分别为可乐定和胰高血糖素，p<0.001），平均峰值功率与体重与 GH 反应之间存在显著相关性（r=0.50，p=0.04）。83%达到峰值功率>10 瓦/千克的参与者 GH 分泌正常。