酰氟作为氟代酮基自由基的直接前体：使用 SmI 和 DO 的还原氘代。
Acyl fluorides as direct precursors to fluoride ketyl radicals: reductive deuteration using SmI and DO.
机构信息
Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
Department of Chemistry and Innovation Center of Pesticide Research, China Agricultural University, Beijing 100193, China.
出版信息
Chem Commun (Camb). 2021 May 25;57(42):5195-5198. doi: 10.1039/d1cc01381e. Epub 2021 Apr 28.
A highly chemoselective reductive deuteration of acyl fluorides to provide α,α-dideuterio alcohols with exquisite levels of deuterium incorporation was developed using SmI and DO as the deuterium source. This method introduces acyl fluorides as attractive radical precursors for the generation of reactive acyl-type fluoride ketyls that should find widespread application in many synthetic strategies involving single electron transfer processes.
发展了一种使用 SmI 和 DO 作为氘源，对酰氟进行高化学选择性还原氘代以提供具有极好氘掺入水平的α,α-二氘代醇的方法。该方法将酰氟作为有吸引力的自由基前体引入，用于生成反应性酰基氟代酮基，这在许多涉及单电子转移过程的合成策略中应该有广泛的应用。
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