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非结核分枝杆菌所致肉芽肿性乳腺炎:诊断与治疗困境

Granulomatous Mastitis Due to Non-Tuberculous Mycobacteria: A Diagnostic and Therapeutic Dilemma.

作者信息

Patel Owais Ahmed, Bakhshi Girish D, Nadkarni Amogh R, Rangwala Zarin S

机构信息

Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai 400008, India.

出版信息

Clin Pract. 2021 Apr 14;11(2):228-234. doi: 10.3390/clinpract11020034.

Abstract

Non-tuberculous mycobacterial (NTM) infections of the breast are rare. These infections present as cellulitis of the breast or breast abscess. Their diagnosis poses a challenge as they manifest signs of acute inflammation, unlike tuberculous mycobacterial infections which present in a chronic pattern. However, on aspiration of pus from the site of infection, primary smear may show acid fast bacilli. This poses a diagnostic dilemma. The present case is that of a 34-year-old woman who presented with recurrent mastitis. She had history of right breast swelling, for which surgical excision had been performed three months prior at another facility. Her histopathology had showed cystic granulomatous neutrophilic mastitis (CNGM). The patient again presented with right breast abscess which was confirmed on ultrasonography. Incision and drainage along with removal of necrotic tissue was done. Primary smear of pus showed acid fast bacilli on Ziehl-Neelson staining. Bacterial culture and line probe speciation revealed non-tuberculous mycobacterium , which responded well to prolonged anti-microbial therapy. These rapidly growing NTM require prolonged treatment and are quite often recurrent. is a rare cause of CNGM, with this being only the third reported case in literature. A brief case report with a review of literature is presented.

摘要

乳腺非结核分枝杆菌(NTM)感染较为罕见。这些感染表现为乳腺蜂窝织炎或乳腺脓肿。由于它们不像以慢性模式出现的结核分枝杆菌感染那样,而是表现出急性炎症的迹象,因此其诊断具有挑战性。然而,从感染部位抽吸脓液时,初次涂片可能显示抗酸杆菌。这就造成了诊断上的两难困境。本病例为一名34岁女性,她反复出现乳腺炎。她有右乳肿胀病史,三个月前在另一家机构接受了手术切除。她的组织病理学检查显示为囊性肉芽肿性中性粒细胞性乳腺炎(CNGM)。患者再次出现右乳脓肿,超声检查得以确诊。进行了切开引流并清除坏死组织。脓液的初次涂片经齐-尼氏染色显示抗酸杆菌。细菌培养和线性探针鉴定显示为非结核分枝杆菌,该菌对延长疗程的抗菌治疗反应良好。这些快速生长的NTM需要长期治疗,且常常复发。NTM是CNGM的罕见病因,这是文献中仅报道的第三例。本文给出了一份简要病例报告并对文献进行了综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5e00/8167781/b961da0f3d85/clinpract-11-00034-g001.jpg

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