预防性高流量湿化温热过滤空气能否提高老年个体细菌性肺炎和新型冠状病毒肺炎的生存率？表面活性蛋白A的作用。
Can Prophylactic High Flow of Humidified and Warmed Filtered Air Improve Survival from Bacterial Pneumonia and SARS-CoV-2 in Elderly Individuals? The Role of Surfactant Protein A.
作者信息
Abbasi Ata, Phelps David S, Ravi Radhika, Floros Joanna
机构信息
Department of Pathology, Urmia University of Medical Sciences, Urmia 5714783734, Iran.
Center for Host Defense, Inflammation, and Lung Disease (CHILD) Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
出版信息
Antioxidants (Basel). 2021 Apr 22;10(5):640. doi: 10.3390/antiox10050640.
Abstract
In this opinion article, we discuss a serendipitous observation we made in a study investigating survival in aged mice after bacterial infection. This observation involved a non-invasive ventilation approach that led to variable and higher survival in male and female mice with different genetic backgrounds for the innate immune molecule, surfactant protein A (SP-A). We suggest that employing the best ventilatory modality, whether that be HFNC or another method, may augment the role of other factors such as SP-A genetics and sex in a personalized approach, and may ultimately improve the outcome.
摘要
在这篇观点文章中，我们讨论了在一项研究老年小鼠细菌感染后存活率的实验中偶然做出的观察。该观察涉及一种无创通气方法，该方法在具有不同先天性免疫分子表面活性蛋白A（SP-A）基因背景的雄性和雌性小鼠中产生了不同且更高的存活率。我们认为，采用最佳的通气方式，无论是高流量鼻导管吸氧（HFNC）还是其他方法，可能会在个性化方法中增强诸如SP-A基因和性别等其他因素的作用，并最终改善结果。
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