Galenok V A, Grinshpun M N, Mazovetskiĭ A G, Dikker V E
Probl Endokrinol (Mosk). 1988 Mar-Apr;34(2):18-20.
In order to determine the diagnostic value of glycolytic hemoglobin (HbA1c) in early forms of diabetes mellitus its content was studied in 62 individuals with disturbed glucose tolerance, then used as a kind of screening for examination of 357 workers employees at a factory with a subsequent glucose tolerance test (GTT). The level of HbA1c was raised almost in all persons with disturbed carbohydrate metabolism. There was correlation between HbA1c and GTT results in the diagnosis of disturbed glucose tolerance. The highest was the correlation between the HbA1c and glycemia in 2 hours during a GTT (r = +0.91). A conclusion was made that the level of HbA1c can serve as a diagnostic criterion of early forms of diabetes mellitus; HbA1c determination taking into account its lesser dependence on the conditions of investigation as compared to GTT, can be used as a method for mass screening and prophylactic medical examination.
为了确定糖化血红蛋白（HbA1c）在早期糖尿病中的诊断价值，对62例糖耐量异常者的糖化血红蛋白含量进行了研究，随后将其作为一种筛查手段，对某工厂357名职工进行检查，并进行了葡萄糖耐量试验（GTT）。几乎所有碳水化合物代谢紊乱者的HbA1c水平均升高。在葡萄糖耐量异常的诊断中，HbA1c与GTT结果之间存在相关性。HbA1c与葡萄糖耐量试验2小时血糖之间的相关性最高（r = +0.91）。得出结论：HbA1c水平可作为早期糖尿病的诊断标准；与葡萄糖耐量试验相比，HbA1c测定对检测条件的依赖性较小，可作为大规模筛查和预防性体检的一种方法。
