[Diagnostic significance of determining glycosylated hemoglobin in the detection of early forms of diabetes mellitus].

In order to determine the diagnostic value of glycolytic hemoglobin (HbA1c) in early forms of diabetes mellitus its content was studied in 62 individuals with disturbed glucose tolerance, then used as a kind of screening for examination of 357 workers employees at a factory with a subsequent glucose tolerance test (GTT). The level of HbA1c was raised almost in all persons with disturbed carbohydrate metabolism. There was correlation between HbA1c and GTT results in the diagnosis of disturbed glucose tolerance. The highest was the correlation between the HbA1c and glycemia in 2 hours during a GTT (r = +0.91). A conclusion was made that the level of HbA1c can serve as a diagnostic criterion of early forms of diabetes mellitus; HbA1c determination taking into account its lesser dependence on the conditions of investigation as compared to GTT, can be used as a method for mass screening and prophylactic medical examination.