通过向腹内侧下丘脑微量注射戊巴比妥来刺激胃酸分泌。

Stimulation of gastric acid secretion by microinjection of pentobarbital into the ventromedial hypothalamus.

作者信息

Lin W C, Yano S, Watanabe K

机构信息

Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 May;60(2):269-72.

PMID:3393736

Abstract

Sites of stimulatory action of pentobarbital on gastric acid secretion were studied in rats anesthetized with urethane. Intracerebroventricular injection of pentobarbital dose-dependently stimulated gastric secretion. When injections of pentobarbital into the ventromedial hypothalamus were repeated with an interval of 30 min, the second and third consecutive injections produced a small but significant increase in gastric acid secretion. We propose that the ventromedial hypothalamus is involved in the stimulatory effect of pentobarbital on gastric acid secretion.

摘要

在使用氨基甲酸乙酯麻醉的大鼠中，研究了戊巴比妥对胃酸分泌的刺激作用部位。脑室内注射戊巴比妥可剂量依赖性地刺激胃酸分泌。当每隔30分钟重复向腹内侧下丘脑注射戊巴比妥时，连续第二次和第三次注射会使胃酸分泌出现小幅但显著的增加。我们认为，腹内侧下丘脑参与了戊巴比妥对胃酸分泌的刺激作用。