红细胞膜微粘度与输血后存活率相关。
Red blood cell membrane microviscosity correlates with posttransfusion survival.
作者信息
McLean L R, Grote C, Silberstein E B, McGill M
机构信息
Merrell Dow Research Institute, Cincinnati, Ohio 45215.
出版信息
Biochem Biophys Res Commun. 1988 Jul 15;154(1):387-91. doi: 10.1016/0006-291x(88)90697-3.
The cholesterol/phospholipid and sphingomyelin/phospholipid ratios of red blood cells stored for 42 days were unchanged after storage. However, the total phospholipid concentration in the red cells decreased suggesting a loss of red cell membrane during storage. The 24 h survival of the stored red cells was assessed by the Cr technique in homologous donors. A decrease in fluorescence polarization of diphenylhexatriene incorporated into the membrane was observed following storage which correlated with survival. Thus, molecular defects in the lipid bilayer are associated with long-term storage of red blood cells.
储存42天的红细胞的胆固醇/磷脂和鞘磷脂/磷脂比率在储存后未发生变化。然而，红细胞中的总磷脂浓度降低，表明储存期间红细胞膜有所损失。通过铬技术在同源供体中评估储存红细胞的24小时存活率。储存后观察到掺入膜中的二苯基己三烯的荧光偏振降低，这与存活率相关。因此，脂质双层中的分子缺陷与红细胞的长期储存有关。
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