Filipović Nika, Šitum Mirna, Buljan Marija
Department of Dermatology and Venereology, University Hospital Centre Sestre Milosrdnice, Zagreb, Croatia.
Department of Dermatovenereology, School of Dental Medicine, University of Zagreb, Croatia.
Dermatol Pract Concept. 2021 Apr 12;11(2):e2021040. doi: 10.5826/dpc.1102a40. eCollection 2021 Mar.
Dermoscopy is a diagnostic tool widely used in clinical practice for the detection of skin tumors, especially early stages of melanoma. Recent studies have shown that different dermoscopic features are associated with important prognostic parameters of melanoma, such as BRAF mutational status and sentinel lymph node status. More than half of all melanomas harbor a mutation in the BRAF oncogene. The current management of advanced-stage melanomas is greatly determined by the presence or absence of a mutation in this gene, as targeted therapy with kinase inhibitors is one of the first therapeutic choices for these patients. Sentinel lymph node status is one of the most significant predictors of a melanoma patient's survival. Recent studies have shown that different dermoscopic patterns are also associated with sentinel lymph node status. This short article reviews studies that investigated correlations between dermoscopic features, mutation status and sentinel lymph node status.
皮肤镜检查是一种在临床实践中广泛用于检测皮肤肿瘤，尤其是黑色素瘤早期阶段的诊断工具。最近的研究表明，不同的皮肤镜特征与黑色素瘤的重要预后参数相关，如BRAF突变状态和前哨淋巴结状态。超过一半的黑色素瘤携带BRAF癌基因突变。晚期黑色素瘤的当前治疗很大程度上取决于该基因是否存在突变，因为激酶抑制剂靶向治疗是这些患者的首要治疗选择之一。前哨淋巴结状态是黑色素瘤患者生存的最重要预测指标之一。最近的研究表明，不同的皮肤镜模式也与前哨淋巴结状态相关。这篇短文回顾了研究皮肤镜特征、突变状态和前哨淋巴结状态之间相关性的研究。
