Wu Zubo, Wu Suyuan, Liang Tao, Wang Lin
Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Neurosci. 2021 Apr 20;15:633022. doi: 10.3389/fnins.2021.633022. eCollection 2021.
To explore the association between lipoprotein-related phospholipase A2 (Lp-PLA2) and the risk of Parkinson's disease (PD).
A case-control study involving 58 hospitalized PD patients and 60 healthy controls was carried out. Serum Lp-PLA2 level was detected. According to the disease course and severity, PD patients were subdivided to analyze the clinical value of Lp-PLA2. Relationship between Lp-PLA2 and PD risk was analyzed by logistic regression. Diagnostic value of Lp-PLA2 in PD patients was investigated using receiver's operator characteristic curves.
Lp-PLA2 level was significantly higher in the PD patients compared with the controls, and was significantly and positively correlated with the Hoehn-Yahr (H&Y) stage. The serum Lp-PLA2 level and H&Y stage of PD patients with a longer disease course were significantly higher than those with a shorter disease course. PD patients with milder conditions had significantly lower serum Lp-PLA2 levels than patients with severe conditions. Multivariable logistic regression analysis indicated higher Lp-PLA2 level was an independent risk factor of PD patients. Moreover, the area under the curve for Lp-PLA2 was 0.703, which was between those of homocysteine and serum amylase A.
To our knowledge, this is the first study to show that increased level of Lp-PLA2 is associated with the risk of PD. Lp-PLA2 may be used for early detection of PD, and provides an effective intervention target for clinical treatment of PD.
探讨脂蛋白相关磷脂酶A2（Lp-PLA2）与帕金森病（PD）风险之间的关联。
开展一项病例对照研究，纳入58例住院的PD患者和60例健康对照。检测血清Lp-PLA2水平。根据病程和严重程度对PD患者进行细分，以分析Lp-PLA2的临床价值。通过逻辑回归分析Lp-PLA2与PD风险之间的关系。使用受试者工作特征曲线研究Lp-PLA2在PD患者中的诊断价值。
与对照组相比，PD患者的Lp-PLA2水平显著更高，且与Hoehn-Yahr（H&Y）分期显著正相关。病程较长的PD患者血清Lp-PLA2水平和H&Y分期显著高于病程较短的患者。病情较轻的PD患者血清Lp-PLA2水平显著低于病情严重的患者。多变量逻辑回归分析表明，较高的Lp-PLA2水平是PD患者的独立危险因素。此外，Lp-PLA2的曲线下面积为0.703，介于同型半胱氨酸和血清淀粉酶A之间。
据我们所知，这是第一项表明Lp-PLA2水平升高与PD风险相关的研究。Lp-PLA2可用于PD的早期检测，并为PD的临床治疗提供有效的干预靶点。
