DeWitt Daughtry Family Department of Surgery, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
Katz Family Division of Nephrology, Department of Medicine, Leonard M. Miller School of Medicine, University of Miami, Miami, FL, USA.
J Vasc Access. 2023 Jan;24(1):99-106. doi: 10.1177/11297298211011875. Epub 2021 May 7.
Neointimal cells are an elusive population with ambiguous origins, functions, and states of differentiation. Expansion of the venous intima in arteriovenous fistula (AVF) is one of the most prominent remodeling processes in the wall after access creation. However, most of the current knowledge about neointimal cells in AVFs comes from extrapolations from the arterial neointima in non-AVF systems. Understanding the origin of neointimal cells in fistulas may have important implications for the design and effective delivery of therapies aimed to decrease intimal hyperplasia (IH). In addition, a broader knowledge of cellular dynamics during postoperative remodeling of the AVF may help clarify other transformation processes in the wall that combined with IH determine the successful remodeling or failure of the access. In this review, we discuss the possible anatomical sources of neointimal cells in AVFs and their relative contribution to intimal expansion.
内膜细胞是一种难以捉摸的细胞群体，其起源、功能和分化状态尚不明确。动静脉瘘（AVF）静脉内膜的扩张是通路建立后血管壁最显著的重塑过程之一。然而，目前关于 AVF 内膜细胞的大部分知识都是从非 AVF 系统的动脉内膜外推而来的。了解瘘管内膜细胞的起源可能对设计和有效传递旨在减少内膜增生（IH）的治疗方法具有重要意义。此外，更广泛地了解 AVF 术后重塑过程中的细胞动力学可能有助于阐明与 IH 相结合的血管壁其他转化过程，从而决定通路的成功重塑或失败。在这篇综述中，我们讨论了 AVF 中内膜细胞的可能解剖来源及其对内膜扩张的相对贡献。
