Medical and Surgical Sciences Dept., Alma Mater Studiorum University of Bologna, Bologna, Italy.
Medical and Surgical Sciences Dept., Alma Mater Studiorum University of Bologna, Bologna, Italy.
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1911-1915. doi: 10.1016/j.numecd.2021.02.034. Epub 2021 Mar 19.
In epidemiological trials and in clinical practices, it is relevant to have affordable and reliable methods to measure the main lipid cardiovascular risk factors, and in particular low-density lipoprotein cholesterol (LDL-C) plasma level. In this context, we aimed to compare the reliability of the Friedewald's (LDL-Cf) and Sampson's (LDL-Cs) equations with the LDL-value dosed by a validated dosage method (LDL-Cd) in a large cohort of children.
We considered the lipid values of 145 infants, 278 preschoolers, 810 scholar children, and 1372 adolescents (Total N. 2605, 1291 males, 1314 females), with mean total cholesterol (TC) = 169.8 ± 39.7 mg/dL, HDL-Cholesterol = 50.8 ± 12.7 mg/dL, non HDL-Cholesterol = 118.9 ± 35.9 mg/dL, Triglycerides (TG) = 90.3 ± 77.9 mg/dL, LDL-Cd = 106.2 ± 29.9 mg/dL, LDL-Cf = 100.9 ± 33.8 mg/dL, and LDL-Cs = 102.2 ± 33.4 mg/dL. Comparing the distance to the LDL-Cd, Friedewald's equation mildly but significantly underestimated in infants (3.4 ± 5.3 mg/dL), preschoolers (1.5 ± 7.1 mg/dL). Children (1.2 ± 2.2 mg/dL) and adolescents (1.1 ± 5.9 mg/dL) compared to Sampson's equation (all comparisons, p < 0.001).
Our analysis, being carried out on a large population sample, shows that Sampson's equation is more reliable than Friedewald's one at each considered age class and even for extreme TG values.
在流行病学研究和临床实践中，需要有经济实惠且可靠的方法来测量主要的血脂心血管风险因素，特别是低密度脂蛋白胆固醇（LDL-C）的血浆水平。在这种情况下，我们旨在比较 Friedewald 方程（LDL-Cf）和 Sampson 方程（LDL-Cs）与经验证的检测方法（LDL-Cd）测量的 LDL 值的可靠性，并在一个大样本的儿童队列中进行评估。
我们分析了 145 名婴儿、278 名学龄前儿童、810 名学龄儿童和 1372 名青少年（总计 2605 名儿童，1291 名男性，1314 名女性）的血脂值，平均总胆固醇（TC）为 169.8±39.7mg/dL，高密度脂蛋白胆固醇（HDL-C）为 50.8±12.7mg/dL，非高密度脂蛋白胆固醇（non-HDL-C）为 118.9±35.9mg/dL，三酰甘油（TG）为 90.3±77.9mg/dL，LDL-Cd 为 106.2±29.9mg/dL，LDL-Cf 为 100.9±33.8mg/dL，LDL-Cs 为 102.2±33.4mg/dL。与 LDL-Cd 相比，Friedewald 方程在婴儿（3.4±5.3mg/dL）、学龄前儿童（1.5±7.1mg/dL）、儿童（1.2±2.2mg/dL）和青少年（1.1±5.9mg/dL）中均轻度但显著低估（所有比较，p<0.001）。
我们的分析结果基于大样本人群，表明在每个考虑的年龄组中，Sampson 方程比 Friedewald 方程更可靠，甚至对于极端 TG 值也是如此。
