纤维蛋白原在脊柱外科手术中的治疗应用：一篇综述文章。
Therapeutic Application of Fibrinogen in Spine Surgery: A Review Article.
作者信息
Barimani Bardia, Moisan Philippe, Santaguida Carlos, Weber Michael
机构信息
Division of Orthopedic Surgery, McGill University, Montreal, Quebec, Canada.
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
出版信息
Int J Spine Surg. 2021 Jun;15(3):549-561. doi: 10.14444/8075. Epub 2021 May 7.
BACKGROUND
The aim of this review is to investigate current uses of fibrinogen as a tool to reduce operative and postoperative blood loss in different surgical fields especially orthopedic spine surgery. This is a systematic review.
METHODS
MEDLINE (via Ovid 1946 to June 1, 2020) and Embase (via Ovid 1947 to June 1, 2020) were searched using the keywords "fibrinogen", "surgery", and "spine" for relevant studies. The search strategy used text words and relevant indexing to identify articles discussing the use of fibrinogen to control surgical blood loss.
RESULTS
The original literature search yielded 407 articles from which 68 duplications were removed. Three hundred thirty-nine abstracts and titles were screened. Results were separated by surgical specialties.
CONCLUSIONS
Multiple studies have looked at the role of fibrinogen for acute bleeding in the operative setting. The current evidence regarding the use of fibrinogen concentrate in spine surgery is promising but limited, even though this is a field with the potential for severe hemorrhage. Further trials are required to understand the utility of fibrinogen concentrate as a first-line therapy in spine surgery and to understand the importance of target fibrinogen levels and subsequent dosing and administration to allow recommendations to be made in this field.
背景
本综述旨在研究纤维蛋白原作为一种减少不同手术领域（尤其是骨科脊柱手术）术中及术后失血工具的当前应用情况。这是一项系统综述。
方法
使用关键词“纤维蛋白原”“手术”和“脊柱”在MEDLINE（通过Ovid检索1946年至2020年6月1日）和Embase（通过Ovid检索1947年至2020年6月1日）中检索相关研究。检索策略使用文本词和相关索引来识别讨论使用纤维蛋白原控制手术失血的文章。
结果
原始文献检索得到407篇文章，其中去除了68篇重复文章。筛选了339篇摘要和标题。结果按手术专科分类。
结论
多项研究探讨了纤维蛋白原在手术中急性出血方面的作用。尽管脊柱手术领域存在严重出血的可能性，但目前关于在脊柱手术中使用纤维蛋白原浓缩物的证据很有前景但有限。需要进一步试验来了解纤维蛋白原浓缩物作为脊柱手术一线治疗方法的效用，以及了解目标纤维蛋白原水平以及后续给药和用药的重要性，以便在该领域提出建议。
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