Department of Ophthalmology, Health Sciences University, Tepecik Training and Research Hospital, Izmir, Turkey; Department of OphthalmOlogy, Health Sciences University, Kayseri Training and Research Hospital, Kayseri, Turkey.
Department of OphthalmOlogy, Health Sciences University, Kayseri Training and Research Hospital, Kayseri, Turkey.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102335. doi: 10.1016/j.pdpdt.2021.102335. Epub 2021 May 8.
To determine and compare the thickness of the ganglion cell-inner plexiform layer (GCIPL), the thickness of the retina nerve fiber layer (RNFL), and the parameters of the optic nerve head (ONH) in exfoliative glaucoma (XFG), primary open-angle glaucoma (POAG), and control eyes using optical coherence tomography (OCT).
The study was a retrospective observational cross-sectional study of 43 eyes of patients with XFG, 44 eyes of patients with POAG, and 37 eyes of healthy participants. Visual acuity, intraocular pressure, central corneal thickness, rim-area, disc-area, average cup/disc ratio, vertical cup/disc ratio, cup volume, average RNFL thickness, and GCIPL (average, minimum, superior, superotemporal, superonasal, inferior, inferotemporal, and inferonasal) thicknesses were determined.
RNFL thicknesses were similar in the XFG and POAG groups (p = 0.065), and both glaucoma groups had significantly thinner RNFLs than the controls (p = 0.002). The XFG group had significantly thinner average and minimum GCIPLs compared to the POAG and control groups (p = 0.027, p < 0.001 for average thickness and p = 0.038, p < 0.001 for minimum thickness, respectively). No significant difference was found in the ONH parameters among the three groups except for rim-area and cup volume (p > 0.05 for all ONH parameters, p < 0.001 for rim-area, and p = 0.003 for cup volume). Mean visual field mean deviation was -11.6 ± 8.2 dB in the XFG group and -10.4 ± 9.3 dB in the POAG group (p = 0.453).
Eyes with XFG were found to have a thinner GCIPL (minimum and average) than eyes with POAG or from healthy controls, although the RNFL measurements were similar to those of eyes with POAG. GCIPL thickness may be a more valuable indicator than RNFL thickness in patients with XFG for early detection of glaucoma and/or for glaucoma progression measurement. There is still some debate in the literature about whether decreases in GCIPL thickness and RNFL thickness (and/or ONH parameter change) are the best indicators for early detection and progress measurement of glaucoma.
使用光学相干断层扫描（OCT）确定并比较剥脱性青光眼（XFG）、原发性开角型青光眼（POAG）和对照组中节细胞-内丛状层（GCIPL）、视网膜神经纤维层（RNFL）的厚度和视盘参数。
这是一项回顾性观察性病例对照研究，纳入了 43 只 XFG 患者的眼、44 只 POAG 患者的眼和 37 只健康对照者的眼。测定视力、眼压、中央角膜厚度、边缘面积、视盘面积、平均杯/盘比、垂直杯/盘比、杯容积、平均 RNFL 厚度和 GCIPL（平均、最小、上、上颞、上鼻、下、下颞、下鼻）厚度。
XFG 组和 POAG 组的 RNFL 厚度相似（p = 0.065），且这两个青光眼组的 RNFL 均明显薄于对照组（p = 0.002）。与 POAG 组和对照组相比，XFG 组的平均和最小 GCIPL 明显更薄（p = 0.027，p < 0.001 为平均厚度，p = 0.038，p < 0.001 为最小厚度）。除边缘面积和杯容积外（所有视盘参数的 p > 0.05，边缘面积的 p < 0.001，杯容积的 p = 0.003），三组间的视盘参数无显著差异。XFG 组平均视野平均偏差为-11.6 ± 8.2 dB，POAG 组为-10.4 ± 9.3 dB（p = 0.453）。
与 POAG 或健康对照组相比，XFG 眼的 GCIPL（最小和平均）更薄，尽管其 RNFL 测量值与 POAG 眼相似。在 XFG 患者中，GCIPL 厚度可能比 RNFL 厚度更能早期发现青光眼和/或测量青光眼进展，其作为指标的价值可能更高。在文献中，关于 GCIPL 厚度和 RNFL 厚度（和/或视盘参数变化）是否是青光眼早期检测和进展测量的最佳指标仍存在一些争议。
