Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Anaesthesiology and Intensive Care, Södersjukhuset, Stockholm, Sweden.
Acta Oncol. 2021 Aug;60(8):1011-1018. doi: 10.1080/0284186X.2021.1921260. Epub 2021 May 11.
The purpose was to investigate whether social distancing during the COVID-19 pandemic reduced health-related quality of life (HRQL) in esophageal cancer patients and if so, to identify factors related to the HRQL changes.
A prospective Swedish nationwide study of patients who undergone surgery for esophageal cancer between 2013 and 2019. Telephone interviews were conducted 5 weeks and 13 weeks after the introduction of social distancing recommendations. The participants responded to a few scales and items from the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire C30. Regression models adjusted for potential confounders were used to examine mean score differences (MSD) with 95% confidence intervals (CI) between compliance with the recommendations and HRQL.
In total, 134 individuals participated in the study. At 5 weeks, a reduction in role function was seen for individuals who fully (MSD -8, 95% CI: -16 to 0) and to a large extent (MSD -19, 95% CI: -26 to -12) complied with the recommendations. Less fatigue (MSD 9, 95% CI: 3-15) was also detected for this group. Being female, elderly, having comorbidities, living in a region with higher COVID-19 incidence, living in a villa, and being considered as an at-risk person were related to changes in role function. At 13 weeks, reductions in role function continued for those who fully complied with the recommendations (MSD -10, 95% CI: -19 to -1), but the risk variables were of less importance. Improvements in fatigue were no longer detected. Global quality of life, emotional function, or insomnia remained stable over time.
This study indicates that individuals who undergone surgery for esophageal cancer and fully or to a large extent complied with the recommendations experienced reductions in role function, but not in global quality of life or emotional function, during the COVID-19 pandemic.
研究 COVID-19 大流行期间的社交距离措施是否降低了食管癌患者的健康相关生活质量（HRQL），如果是，确定与 HRQL 变化相关的因素。
这是一项针对 2013 年至 2019 年间接受食管癌手术的患者的前瞻性瑞典全国性研究。在实施社会距离建议后 5 周和 13 周进行电话访谈。参与者回答了欧洲癌症研究和治疗组织生活质量问卷 C30 的一些量表和项目。使用调整了潜在混杂因素的回归模型来检查建议遵守情况与 HRQL 之间的平均得分差异（MSD）及其 95%置信区间（CI）。
共有 134 名患者参与了这项研究。在 5 周时，完全（MSD-8，95%CI：-16 至 0）和很大程度上（MSD-19，95%CI：-26 至-12）遵守建议的患者，角色功能下降。该组还检测到疲劳减轻（MSD 9，95%CI：3-15）。女性、年龄较大、合并症、生活在 COVID-19 发病率较高的地区、居住在别墅中以及被认为是高危人群与角色功能的变化有关。在 13 周时，对于完全遵守建议的患者，角色功能的下降仍在继续（MSD-10，95%CI：-19 至-1），但风险变量的重要性降低。疲劳的改善不再被检测到。全球生活质量、情绪功能或失眠在整个研究过程中保持稳定。
本研究表明，接受食管癌手术且完全或在很大程度上遵守建议的患者在 COVID-19 大流行期间经历了角色功能下降，但全球生活质量或情绪功能没有下降。
