根据孕龄分布的二倍体和二倍体三倍体。
Distribution of diandric and digynic triploidy depending on gestational age.
机构信息
Department of Gynecologic Oncology and Obstetrics, Centre of Postgraduate Medical Education, Czerniakowska 231, 00-416, Warsaw, Poland.
Department of Genetics, Institute of Psychiatry and Neurology, Sobieskiego 9, 02-957, Warsaw, Poland.
出版信息
J Assist Reprod Genet. 2021 Sep;38(9):2391-2395. doi: 10.1007/s10815-021-02202-4. Epub 2021 May 13.
PURPOSE
To establish the distribution of diandric and digynic triploidy depending on gestational age.
METHODS
107 triploid samples tested prospectively in a single genetic department during a four-year period were analyzed for parental origin of triploidy by Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR) (n=95) with the use of matching parental samples or by MS-MLPA (n=12), when parental samples were unavailable. Tested pregnancies were divided into three subgroups with regard to the gestational age at spontaneous pregnancy loss: <11 gestational weeks, 11-14 gestational weeks, and >14 gestational weeks.
RESULTS
Diandric triploidy constituted overall 44.9% (46.5% in samples miscarried <11 gestational weeks, 64.3% in samples miscarried between 11 and 14 gestational weeks, and 27.8% in pregnancies which survived >14 gestational weeks).
CONCLUSIONS
The distribution of diandric and digynic triploidy depends on gestational age. The majority of diandric triploid pregnancies is lost in the first trimester of pregnancy. In the second trimester, diandric cases are at least twice less frequent than digynic ones.
目的
根据孕龄确定二倍体和二倍体三倍体的分布。
方法
在四年期间，我们在一个遗传科对 107 个经前瞻性检测的三倍体样本进行了分析，通过定量荧光聚合酶链反应（QF-PCR）（n=95），使用匹配的双亲样本或当双亲样本不可用时使用 MS-MLPA（n=12），来确定三倍体的双亲来源。将经检测的妊娠分为三组，根据自发妊娠丢失的孕龄进行分组：<11 孕周、11-14 孕周和>14 孕周。
结果
二倍体三倍体总体构成 44.9%（<11 孕周的流产样本中占 46.5%，11-14 孕周的流产样本中占 64.3%，>14 孕周的存活妊娠中占 27.8%）。
结论
二倍体和二倍体三倍体的分布取决于孕龄。大多数二倍体三倍体妊娠在妊娠的前三个月丢失。在孕中期，二倍体病例的发生率至少比二倍体病例低两倍。
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