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神经调节治疗术后硬膜外纤维化:硬膜外纤维化程度的比较和刺激效果。

Neuromodulation in the treatment of postoperative epidural fibrosis: comparison of the extent of epidural fibrosis and the effect of stimulation.

机构信息

Department of Neurosurgery and Neurooncology, First Faculty of Medicine, Charles University, Prague 6, Czech Republic.

出版信息

Physiol Res. 2021 Jul 12;70(3):461-468. doi: 10.33549/physiolres.934617. Epub 2021 May 12.

Abstract

The goal was to prove that when a cohort of patients is chosen precisely, dorsal column stimulation provides significant improvement to quality of life. We studied a cohort of 50 patients with the history of failed back surgery syndrome coupled with epidural fibrosis (EF). A percutaneous implantation technique was used in each of the 50 patients. The study group was composed of 20 women and 28 men aged 26-67 years (mean age 49). A prospective observational questionnaire-based study was used. According to the methods, Ross's classification was adjusted to four degrees of scar size for our study objective. Despite this adjustment, it was not possible to statistically evaluate our research, due to very similar results in Groups I, III and IV. Patients without epidural fibrosis were assigned to Group 0, and patients with EF of different ranges were assigned to Group 1. The mean change in visual analogue scale DeltaVAS after our division into Group 0 was 4.82; for Group 1 it was 6.13. Evaluation of EF and DeltaVAS correlation by paired t-test shows a statistically higher effect of spinal cord stimulation (SCS) in the epidural fibrosis group, compared to group 0 without postoperative epidural fibrosis (p=0.008). The extent of epidural fibrosis is an important factor for Failed back surgery syndrome (FBSS). FBSS is the basis for the existence of neuropathic pain after lumbar spinal surgery. There is clear evidence of a correlation between patients with epidural scar formation on MR scan and the effect of dorsal column stimulation.

摘要

目的是证明当精确选择患者队列时,背柱刺激可显著提高生活质量。我们研究了 50 例有失败的腰椎手术综合征病史且伴有硬膜外纤维化(EF)的患者队列。在这 50 例患者中,每位患者均使用经皮植入技术。研究组由 20 名女性和 28 名年龄在 26-67 岁(平均年龄 49 岁)的男性组成。采用前瞻性观察问卷调查研究。根据方法,Ross 分类法为我们的研究目标调整为四个疤痕大小等级。尽管进行了这种调整,但由于 I、III 和 IV 组的结果非常相似,因此无法对我们的研究进行统计学评估。没有硬膜外纤维化的患者被分到第 0 组,而硬膜外纤维化程度不同的患者被分到第 1 组。我们将患者分为第 0 组后,视觉模拟量表 DeltaVAS 的平均变化为 4.82;对于第 1 组,其平均变化为 6.13。配对 t 检验评估 EF 和 DeltaVAS 的相关性显示,与无术后硬膜外纤维化的第 0 组相比,硬膜外纤维化组脊髓刺激(SCS)的效果具有统计学上的显著提高(p=0.008)。硬膜外纤维化的程度是失败的腰椎手术综合征(FBSS)的一个重要因素。FBSS 是腰椎手术后出现神经性疼痛的基础。硬膜外疤痕形成的患者在 MR 扫描上与背柱刺激的效果之间存在明显的相关性。

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本文引用的文献

1
Electrode movement prevention - an animal model.
Physiol Res. 2019 Aug 29;68(4):667-673. doi: 10.33549/physiolres.933997. Epub 2019 Jun 6.
2
The glycation products before and after therapy for acute and chronic pain.
Physiol Res. 2018 Dec 31;67(Suppl 4):S685-S688. doi: 10.33549/physiolres.933984.
3
The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.
Pain. 2019 Jan;160(1):53-59. doi: 10.1097/j.pain.0000000000001365.
4
The Results of Treating Failed Back Surgery Syndrome by Adhesiolysis: Comparing the One- and Three-Day Protocols.
Anesth Pain Med. 2017 Aug 22;7(5):e60271. doi: 10.5812/aapm.60271. eCollection 2017 Oct.
5
Hemostasis vs. epidural fibrosis?: A comparative study on an experimental rat model of laminectomy.
Neurol Neurochir Pol. 2016;50(5):323-30. doi: 10.1016/j.pjnns.2016.05.002. Epub 2016 May 25.
7
Wound drains in posterior spinal surgery: a meta-analysis.
J Orthop Surg Res. 2016 Jan 22;11:16. doi: 10.1186/s13018-016-0351-8.
10
Preventive effect of dexamethasone gelatin sponge on the lumbosacral epidural adhesion.
Int J Clin Exp Med. 2015 Apr 15;8(4):5478-84. eCollection 2015.

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