Environmental Health and Radiological Sciences Department, Colorado State University, Veterinary Teaching Hospital, Fort Collins, Colorado, USA.
Vet Comp Oncol. 2022 Mar;20(1):59-68. doi: 10.1111/vco.12706. Epub 2021 May 20.
Metabolic tumour volumes (MTV) and total lesion glycolysis (TLG) are metabolic parameters that are becoming more commonly reported in human medicine to quantify tumours detected on fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT). In this retrospective study dogs afflicted with appendicular osteosarcoma that were staged with F-FDG PET/CT had MTV and TLG at a variety of set and fixed thresholds calculated by two observers. These values, along with SUV , were evaluated for prognostic significance in this population of dogs. There was excellent correlation between two observers for all values. Multiple volumetric parameters were significantly associated with survival. SUV had the highest sensitivity for survival and TLG at 2.5 SUVcm had the highest specificity for prediction of survival based on ROC calculations. The SUV , MTV at 2.5 SUV and TLG at 2.5 SUVcm were significantly different between dogs that survived more than or less than 1 year. This study is the first of its kind in veterinary medicine that retrospectively evaluated volumetric tumour values for prognostic significance and may provide a basis for standardized method of reporting F-FDG PET/CT results.
代谢肿瘤体积（MTV）和总病灶糖酵解（TLG）是医学领域中越来越常用的代谢参数，用于量化氟-18 氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-FDG PET/CT）检测到的肿瘤。在这项回顾性研究中，接受 F-FDG PET/CT 分期的患有附肢骨肉瘤的犬，由两位观察者在各种设定和固定阈值下计算 MTV 和 TLG。在这群犬中，评估了这些值与预后的相关性。所有值在两位观察者之间都有很好的相关性。多个体积参数与生存显著相关。SUV 对生存的敏感性最高，而 SUVcm 为 2.5 的 TLG 对预测生存的特异性最高，这是基于 ROC 计算得出的。SUV、SUV 为 2.5 的 MTV 和 SUVcm 为 2.5 的 TLG 在生存时间超过或少于 1 年的犬之间存在显著差异。这是兽医领域中首次回顾性评估体积肿瘤值的预后意义的研究，可能为 F-FDG PET/CT 结果的标准化报告方法提供依据。
